Evidence map›Paper›PMID 33042589›Full record

ArticleJournal of translational science2020

Pharmacological approaches to the treatment of COVID-19 patients.

Lawrence C Sowers, Lucas S Blanton, Scott C Weaver, Randall J Urban, Charles P Mouton

Open access · diamondAbstract read
In one paragraph

Article in Journal of translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.0field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lawrence C SowersDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas.
Lucas S BlantonDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Scott C WeaverDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas.
Randall J UrbanDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Charles P MoutonDepartment of Family Medicine, University of Texas Medical Branch, Galveston, Texas.
The University of Texas Medical Branch at Galveston · US

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
BASE PAIRING AND MUTAGENESISR01GM041336 · NIGMS · LOMA LINDA UNIVERSITY · PI SOWERS, LAWRENCE C · 1995 to 2007
$2.3M
Oxidation of 5-methylcytosine: DNA damage and epigenetic reprogrammingR01CA184097 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SOWERS, LAWRENCE C, ZHANG, KANGLING · 2014 to 2018
$1.6M
NCATS NIH HHS UL1 TR001439NCI NIH HHS R01 CA184097NIAID NIH HHS R24 AI120942NIGMS NIH HHS R01 GM041336
6 · The paper itself

Abstract

The current COVID-19 pandemic has presented unprecedented challenges to the world community. No effective therapies or vaccines have yet been established. Upon the basis of homologies to similar coronaviruses, several potential drug targets have been identified and are the focus of both laboratory and clinical investigation. The rationale for several of these drug candidates is presented in this review. Emerging clinical data has revealed that severe COVID-19 disease is associated with heightened inflammatory responses and a procoagulant state, suggesting that patient treatment strategies must extend beyond antiviral agents. Effective approaches to the treatment of vulnerable patients with comorbidities will render COVID-19 substantially more manageable.

Indexed as

antiviralcoagulationcoronavirusCOVID-19inflammationSARS-CoV-2

Identifiers

PMID33042589
PMCPMC7543691
OpenAlexW3083319087

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.