Evidence map›Paper›PMID 33042520›Full record

ArticleF1000Research2020

Case Report: IgG multiple myeloma and chronic myeloid leukemia in a single patient.

Neeraja Swaminathan, Sorab Gupta, Claudia Dourado

Open access · goldAbstract readCase Reports
In one paragraph

Article in F1000Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Neeraja SwaminathanDepartment of Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, 19141, USA.ORCID 0000-0002-9043-0420
Sorab GuptaDepartment of Hematology, Albert Einstein Medical Center, Philadelphia, PA, 19141, USA.
Claudia DouradoDepartment of Hematology, Albert Einstein Medical Center, Philadelphia, PA, 19141, USA.
Einstein Medical Center Philadelphia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 58-year-old man presented with recurrence of chronic myeloid leukemia (CML) after complete molecular remission in the setting of non-compliance with imatinib. He was restarted on imatinib and was also noted to have IgG kappa monoclonal gammopathy of undetermined significance (MGUS). The patient re-achieved molecular remission after resumption of imatinib, but his MGUS progressed to smoldering myeloma and he was eventually diagnosed with multiple myeloma (MM) and initiated on treatment for MM with thalidomide, bortezomib and dexamethasone. He has responded well to treatment of the myeloma and continues concurrent maintenance imatinib treatment for CML and is being evaluated for bone marrow transplant. The association of two concurrent hematological malignancies, CML and MM, is very rare and has been infrequently reported in literature. The pathophysiology of this has not yet been fully understood. This case report reviews the various theories to explain this and discusses the potential challenges of simultaneous treatment of MM and CML.

Indexed as

Leukemia, Myelogenous, Chronic, BCR-ABL PositiveMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaBortezomibDexamethasoneHumansImatinib MesylateImmunoglobulin GMaleMiddle AgedThalidomideBortezomibDexamethasoneImatinib MesylateImmunoglobulin GThalidomidechronic myeloid leukemiaCMLMGUSmultiple myeloma

Identifiers

PMID33042520
PMCPMC7527863
OpenAlexW3029089834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.