ReviewAmerican journal of translational research2020
Emerging roles of long non-coding RNAs in osteonecrosis of the femoral head.
Review in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Advances in the mechanism for steroid-induced osteonecrosis of the femoral head.Bone research · 2026Review
- microRNA-576-5p ameliorates dexamethasone-induced BMSC injury by suppressing ANXA2.Scientific reports · 2025Article
- Emerging perspectives on osteonecrosis of the femoral head: the role of circular RNAs and long non-coding RNAs - a systematic review.Frontiers in genetics · 2025Review
- Article
- Differentially Expressed Circulating Long-Noncoding RNAS in Premature Infants with Respiratory Distress Syndrome.Balkan journal of medical genetics : BJMG · 2023Article
- LncAABR07053481 inhibits bone marrow mesenchymal stem cell apoptosis and promotes repair following steroid-induced avascular necrosis.Communications biology · 2023Article
- IRF8 and its related molecules as potential diagnostic biomarkers or therapeutic candidates and immune cell infiltration characteristics in steroid-induced osteonecrosis of the femoral head.Journal of orthopaedic surgery and research · 2023Article
- Review
- MIR31HG polymorphisms are related to steroid-induced osteonecrosis of femoral head among Chinese Han population.BMC musculoskeletal disorders · 2022Article
- CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7.Molecular therapy. Nucleic acids · 2022Article
- Long Noncoding RNA Zinc Finger Antisense 1 Affects Glucocorticoid-Induced Osteonecrosis of the Femoral Head by Performing as a ceRNA for MicroRNA-124-3p and Accelerating Transforming Growth Factor Type III Receptor.Computational and mathematical methods in medicine · 2022Article
- Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/β-catenin pathway.BMC complementary medicine and therapies · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteonecrosis of the femoral head (ONFH) is a potentially disabling orthopedic condition that, in most late-stage cases, requires total hip arthroplasty. Although direct trauma to the hip (e.g. femoral neck fracture, hip dislocation) that leads to vascular interruption is a strong risk factor for ONFH, there are many non-traumatic risk factors (e.g. use of corticosteroid, alcohol abuse) which molecular mechanisms in ONFH still remain obscured. Long non-coding RNAs (lncRNAs) is a class of regulatory RNAs that play crucial roles in various cellular functions, including cell proliferation, invasion, metabolism, apoptosis and stem cell differentiation. Recent studies also suggested their participation in bone development and regeneration, and a direct involvement in the pathogenesis of numerous of orthopaedic conditions, such as ONFH. LncRNAs are differentially expressed in ONFH tissues as well as bone marrow-mesenchymal stem cells and bone microvascular endothelial cells isolated from ONFH patients. Functional studies further established their critical roles in regulating biological processes, such as osteoblast survival and osteogenic differentiation of bone marrow-mesenchymal stem cells, which are closely related to ONFH. The current review aims at summarizing the recent advancement in this field and discussing the potential diagnostic, prognostic and therapeutic utilities of lncRNAs in the clinical management of ONFH.
Indexed as
Identifiers
33042474PMC7540093What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.