Evidence map›Paper›PMID 33042468›Full record

ArticleAmerican journal of translational research2020

CD47 antibody suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.

Yong Li, Xuguan Chen, Peng Li, Qianxuan Xiao, Daorong Hou, Xiangqing Kong

Abstract read
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Autophagy in Heart Failure: Insights into Mechanisms and Therapeutic Implications.Journal of cardiovascular development and disease · 2023
    Review
  7. Emerging phagocytosis checkpoints in cancer immunotherapy.Signal transduction and targeted therapy · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yong LiDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, P. R. China.
Xuguan ChenDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, P. R. China.
Peng LiDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, P. R. China.
Qianxuan XiaoDepartment of Stomatology, Nanjing Medical University Nanjing 211166, Jiangsu Province, P. R. China.
Daorong HouKey Laboratory of Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University Nanjing 211166, Jiangsu Province, P. R. China.
Xiangqing KongDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, Jiangsu Province, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated whether CD47 antibody could attenuate isoproterenol (ISO)-induced cardiac hypertrophy in mice and H9C2 cells. Cardiac hypertrophy was induced by intraperitoneal (i.p.) injection of ISO (60 mg.kg

Indexed as

apoptosisautophagyCardiac hypertrophyCD47 antibodyoxidative stress

Identifiers

PMID33042468
PMCPMC7540123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.