Evidence map›Paper›PMID 33042414›Full record

ArticleAmerican journal of translational research2020

Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis.

Yi Zhang, Qingyang Liang, Yanan Zhang, Lei Hong, Da Lei, Li Zhang

Abstract read
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Emerging Role of Non-Coding RNAs in Senescence.Frontiers in cell and developmental biology · 2022
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi ZhangDepartment of Cardiology, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, Guangdong, China.
Qingyang LiangDepartment of Cardiology, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, Guangdong, China.
Yanan ZhangCollege of Veterinary Medicine, Northeast Agricultural University Harbin 150030, China.
Lei HongDepartment of Cardiology, Long Gang Central Hospital of Shenzhen Shenzhen 518116, Guangdong, China.
Da LeiDepartment of Cardiology, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, Guangdong, China.
Li ZhangDepartment of Cardiology, The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olmesartan (OMST) is a new angiotensin II receptor antagonist recently approved by the FDA to treat cardiovascular diseases. We investigated the molecular mechanisms by which OMST regulates vascular senescence. In the present study, bleomycin (BLM) was used to induce senescence in vascular smooth muscle cells (VSMCs); after which, the cells were treated with OMST. The effects of OMST on BLM-mediated cell senescence were evaluated using cell adhesion, NAD

Indexed as

AtherosclerosisMiR-665olmesartanSDC1vascular smooth muscle cell senescence

Identifiers

PMID33042414
PMCPMC7540088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.