Evidence map›Paper›PMID 33042410›Full record

ArticleAmerican journal of translational research2020

Urine-derived stem cells accelerate the recovery of injured mouse hepatic tissue.

Chaoqun Hu, Yun He, Shuyu Fang, Na Tian, Mengjia Gong, Xiaohui Xu, Li Zhao, Yi Wang, Tongchuan He, Yuanyuan Zhang and 1 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Chaoqun HuStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Yun HeStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Shuyu FangStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Na TianStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Mengjia GongStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Xiaohui XuStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Li ZhaoStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Yi WangStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Tongchuan HeMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center Chicago, Illinois, USA.
Yuanyuan ZhangStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
Yang BiStem Cell Biology and Therapy Laboratory, Children's Hospital of Chongqing Medical University Chongqing, P. R. China.
University of Chicago Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urine-derived stem cells (USCs) are autologous stem cells that exhibit self-renewal ability and multi-lineage differentiation potential. These characteristics make USCs an ideal cell source for hepatocellular transplantation. Here, we investigated the biological characteristics of USCs and their potential use for the treatment of chronic liver injury. We characterized the cell-surface marker profile of USCs by flow cytometry and determined the osteogenic, adipogenic, and hepatic differentiation capacities of USCs using histology. We established a chronic liver-injury model by intraperitoneally injecting carbon tetrachloride into nude mice. USCs were then transplanted via tail vein injection. To determine liver function and histopathology following chronic liver injury, we calculated the liver index, measured serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and performed histological staining. USCs were small, adherent cells expressing mesenchymal but not hematopoietic stem-cell markers. Some induced USCs underwent osteogenic and adipogenic differentiation. When co-cultured with hepatic progenitor cells, about 10% of USCs underwent hepatic differentiation. The ALT and AST levels of the USC-transplanted group were lower than that of the chronic liver-injury model group, and there were no significant differences between the two USC-transplanted groups. However, hepatocyte degeneration and liver fibrosis substantially improved in the hypoxia-pretreated USC-transplanted group compared with the normoxia USC-transplanted group. Taken together, USCs display desirable proliferation and differentiation characteristics, and USC transplantation partially improves abnormal liver function and pathology associated with chronic liver injury. Furthermore, hypoxia pretreatment promotes cell proliferation, migration, and colony formation by inducing autophagy, leading to USC-elicited liver tissue recovery following injury

Indexed as

autophagycell transplantationchronic liver injuryhypoxiaUrine-derived stem cells

Identifiers

PMID33042410
PMCPMC7540109
OpenAlexW3092128475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.