Evidence map›Paper›PMID 33042359›Full record

ArticleThe World Allergy Organization journal2020

A new form of irritant rhinitis to filtering facepiece particle (FFP) masks (FFP2/N95/KN95 respirators) during COVID-19 pandemic.

Ludger Klimek, Tilman Huppertz, Ali Alali, Magdalena Spielhaupter, Karl Hörmann, Christoph Matthias, Jan Hagemann

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. ENT symptoms of mask-wearing in the coronavirus disease 2019 era.The Journal of laryngology and otology · 2022
    Article
  10. Recent advances in facemask devices forTrends in analytical chemistry : TRAC · 2022
    Review
  11. Review
  12. Filtering efficiency measurement of respirators by laser-based particle counting method.Measurement : journal of the International Measurement Confederation · 2021
    Article
  13. Review
  14. SARS-COV-2, can you be over it?The World Allergy Organization journal · 2021
    Review
  15. [Use of masks by children to prevent infection with SARS-CoV-2].Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ludger KlimekCentre for Rhinology and Allergology, Wiesbaden, Germany.
Tilman HuppertzDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center, Mainz, Germany.
Ali AlaliCentre for Rhinology and Allergology, Wiesbaden, Germany.
Magdalena SpielhaupterORL Clinic, Taunusstein, Germany.
Karl HörmannMannheim University Hospital, Mannheim, Germany.
Christoph MatthiasDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center, Mainz, Germany.
Jan HagemannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Center, Mainz, Germany.
Johannes Gutenberg University Mainz · DEZentrum für Rhinologie und Allergologie · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Filtering facepiece particle (FFP) masks are important items of personal protective equipment in fighting COVID-19 pandemic. They shall protect the wearer of the mask from particles, droplets, and aerosols, but they also can prevent the spread of aerosol-transmitted viruses if the wearer becomes infected. Most often, FFP respirators consist of multiple layers of non-woven fabric made from polypropylene. Worldwide, FFP respirators are subject to various regulatory standards that specify physical properties and performance characteristics. During the SARS-CoV-2 pandemic, health authorities have temporarily repealed standards for respirators. We report on 46 patients that presented with rhinitis-like symptoms strongly associated to the use of FFP masks. Some of them were obliged to use FFP masks in their work environment. Nasal endoscopy showed edemata of the nasal mucosa that significantly decreased after a period of non-use of FFP masks. Subjectively reported symptom levels decreased after cessation of FFP use for 3 or more days. The presence of polypropylene fibres isolated from nasal rinsing solution was significantly associated with the use of FFP masks in our patients. Material safety and performance deregulation of FFP masks can pose a health risk. Thus, especially health care professionals and other individuals with occupational need for FFP masks should be aware of possible hazards that come with COVID-19 pandemic protection measures.

Indexed as

AllergyCE, conformité européenne label indicating conformity to the EU-regulation 765/2008COVID-19, coronavirus disease from the year 2019ECP, eosinophilic cationic proteinFFP2-MaskFFP, filtering facepiece particleFiltering facepiece masksIrritant rhinitisKN95-MaskN95 / KN95, technical / physical standard for filtering face masks (not penetrated by particles larger 0.3 μm, N/KN indicating that aqueous, but not oily aerosols are filteredN95-maskPPE, personal protective equipmentSD / SEM, standard deviation / standard error of the meanVAS, visual analogue scaleWHO, World Health Organization

Identifiers

PMID33042359
PMCPMC7538121
OpenAlexW3089621122

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.