ArticleInternational journal of clinical and experimental pathology2020
Expression of PI3K and ERK in Uygur and Han patients with cervical squamous cancer.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Expression Analysis of the orphan receptors GPR161, GPR132, GPR20, and GPR139 in patients with cervicitis and low-grade, and high-grade squamous intraepithelial lesions.Genetics and molecular biology · 2026Article
- The relationship between human papillomavirus genotype distribution and age and the association with high-grade squamous intraepithelial lesions of the cervix or cervical cancer in Jilin Province, China.Virology journal · 2025Article
- Human Papilloma Virus: Current Knowledge and Focus on Oral Health.BioMed research international · 2021Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical squamous cancer is a common malignancy of the female reproductive system, and the age of onset is getting younger. PI3K and ERK, are key components in maintaining the development of malignant tumor, but have not been studied in cervical squamous cancer. Objective: To explore the differences in disease susceptibility to human papilloma virus-16 (HPV-16), phosphoinositide 3 kinase (PI3K) and extracellular signal regulating kinase (ERK) protein expression in cervical squamous cancer tissues between Uyghur and Han women. The expression of PI3K and ERK and presence of HPV-16 infection were detected by polymerase chain reaction (PCR) and S-P immunohistochemical assay in cervical squamous carcinoma tissue. To detect PI3K and ERK expression in cervical squamous carcinoma tissue and HPV-16 infection condition, polymerase chain reaction (PCR) and S-P immunohistochemical assay were used. HPV-16 infection rate in cervical squamous cancer tissue of Uighur women (40.43%) was significantly higher than Han women (8.33%) (P < 0.05). The positive expression of PI3K in cervical squamous carcinoma tissues was 92.41% (Uyghur nationality: 93.09%; Han nationality: 88.89%), and no statistical difference was observed between Uyghur and Han women (
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33042338PMC7539876What OpenQuestion holds
Registered trials
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