ArticleInternational journal of clinical and experimental pathology2020
Estrogen receptor alpha expression in renal tissue and its relationship with prognosis in immunoglobulin A nephropathy.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aromatase enzyme: Paving the way for exploring aromatization for cardio-renal protection.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Pooled it
- Ovarian hormones moderate systolic hypertension in femaleAmerican journal of physiology. Renal physiology · 2026Article
- The double-edged sword effect of estrogen in kidney disease and its precision modulation.Frontiers in endocrinology · 2026Review
- Pharmacotherapeutic considerations of selective estrogen receptor modulators for vascular protection.Frontiers in pharmacology · 2026Review
- Ovarian Hormones Moderate Systolic Hypertension in FemalebioRxiv : the preprint server for biology · 2025Article
- Role of Sex Hormones in Prevalent Kidney Diseases.International journal of molecular sciences · 2023Review
- Clinicopathological characteristics and risk factors in elderly patients with biopsy-proven IgA nephropathy.Renal failure · 2022Article
- Estradiol Ameliorates Acute Kidney Ischemia-Reperfusion Injury by Inhibiting the TGF-βRI-SMAD Pathway.Frontiers in immunology · 2022Article
- Estrogen and estrogen receptors in kidney diseases.Renal failure · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEpidemiologic studies have shown that, compared to men, women have better prognoses in chronic renal diseases. This indicates that gender hormones may have some effect on renal function. The present study aimed to investigate the expression and relationship with prognosis of estrogen receptor alpha (ERα) in renal tissue of immunoglobulin A nephropathy (IgAN) patients.
methodsExpression of ERα was detected by immunohistochemistry. Specimens were collected from forty-five IgAN patients and five normal healthy participants. In addition to expression, the relationship of ERα with clinical data, prognosis, and the degree of glomerular damage were analyzed.
resultsERα was expressed in the glomeruli and renal tubules. The expression of ERα in the glomeruli of IgAN renal tissue decreased gradually (
conclusionsThe expression of ERα in the renal tissue of IgAN patients was reduced and there was a correlation with the degree of kidney damage and prognosis, suggesting that ERα may play a role in the progression of IgAN.
Indexed as
Identifiers
33042337PMC7539875What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.