ArticleInternational journal of clinical and experimental pathology2020
The expression of the circadian gene TIMELESS in non-small-cell lung cancer and its clinical significance.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Article
- SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells.PloS one · 2024Article
- The role of circadian clocks in cancer: Mechanisms and clinical implications.Genes & diseases · 2023Review
- Association of the Timeless Gene with Prognosis and Clinical Characteristics of Human Lung Cancer.Diagnostics (Basel, Switzerland) · 2022Article
- Circadian Rhythm Dysregulation and Leukemia Development: The Role of Clock Genes as Promising Biomarkers.International journal of molecular sciences · 2022Review
- Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm.Frontiers in bioscience (Landmark edition) · 2021Review
- Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways.Biomolecules · 2021Review
- Nicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes.Current neurovascular research · 2020Review
- Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer.Integrative cancer therapiesArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to explore the relationship between the circadian gene TIMELESS (TIM) in non-small-cell lung cancer (NSCLC) and prognosis, so as to provide a reference for subsequent targeted therapy and patient prognosis. A total of 72 patients with NSCLC were selected as the study cohort. Immunohistochemistry and Western blot were used to measure the expressions of TIM in NSCLC and para-carcinoma tissues (PCT). RT-qPCR was used to measure the mRNA expression of TIM. The Kaplan-Meier method was further utilized to generate survival curves for a log-rank test single-factor analysis and a Cox regression multi-factor analysis. The relationship between the TIM gene expression and the clinical features and survival were explored. The results indicated that the mRNA and protein expressions of TIM in the NSCLC tissues were higher than those in the PCT (
Indexed as
Identifiers
33042334PMC7539872What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.