Evidence map›Paper›PMID 33042271›Full record

ArticleTheranostics2020

Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in Colorectal Cancer.

Rui Cao, Fan Yang, Si-Cong Ma, Li Liu, Yu Zhao, Yan Li, De-Hua Wu, Tongxin Wang, Wei-Jia Lu, Wei-Jing Cai and 10 more

Open access · goldAbstract readValidation Study
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 4 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 4 syntheses or guidelines pooled it, 252 citations in OpenAlex.

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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Rui CaoInformation Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fan YangAI Lab, Tencent, Shenzhen, China.
Si-Cong MaDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li LiuInformation Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yu ZhaoAI Lab, Tencent, Shenzhen, China.
Yan LiDepartment of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
De-Hua WuDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Tongxin WangIndiana University Bloomington, Bloomington, USA.
Wei-Jia LuAI Lab, Tencent, Shenzhen, China.
Wei-Jing CaiTongshu Biotechnology Co., Ltd. Shanghai, China.
Hong-Bo ZhuInformation Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xue-Jun GuoDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yu-Wen LuDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jun-Jie KuangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wen-Jing HuanTencent Healthcare, Shenzhen, China.
Wei-Min TangTencent Healthcare, Shenzhen, China.
Kun HuangDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Junzhou HuangAI Lab, Tencent, Shenzhen, China.
Jianhua YaoAI Lab, Tencent, Shenzhen, China.
Zhong-Yi DongDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nanfang Hospital · CNTencent (China) · CNSouthern Medical University · CNTencent Healthcare (China) · CNHuazhong University of Science and Technology · CNIndiana University Bloomington · USIndiana University School of Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsatellite instability (MSI) has been approved as a pan-cancer biomarker for immune checkpoint blockade (ICB) therapy. However, current MSI identification methods are not available for all patients. We proposed an ensemble multiple instance deep learning model to predict microsatellite status based on histopathology images, and interpreted the pathomics-based model with multi-omics correlation.

Indexed as

Microsatellite InstabilityBiomarkers, TumorCohort StudiesColonColorectal NeoplasmsDatasets as TopicDeep LearningDNA DamageDNA RepairDrug Resistance, NeoplasmGene Expression ProfilingGenomicsHumansImage Interpretation, Computer-AssistedImmune Checkpoint InhibitorsModels, GeneticBiomarkers, TumorImmune Checkpoint Inhibitorscolorectal cancerensembled patch likelihood aggregation (EPLA)microsatellite instabilitymulti-omicspathomics

Identifiers

PMID33042271
PMCPMC7532670
OpenAlexW3084161163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.