ArticleBioPsychoSocial medicine2020
Association between polypharmacy and the persistence of delirium: a retrospective cohort study.
Article in BioPsychoSocial medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and determinants of polypharmacy among cancer patients: a systematic review and meta-analysis.Systematic reviews · 2026Pooled it
- Venlafaxine and Delirium: Understanding the Association.Current neuropharmacology · 2026Review
- Cross national pharmacovigilance analysis of drug-induced delirium: a comparative study using the US FAERS, Japanese JADER, and canadian CVAR datasets.Frontiers in pharmacology · 2026Article
- Prediction of Depression and Anxiety Symptoms in Older Adults from Objectively Measured Physical Activity.International journal of behavioral medicine · 2025Article
- The intersection of delirium and long-term cognition in older adults: the critical role of delirium prevention.Journal of neurology · 2025Review
- Risk factors and outcomes of hyperactive delirium in older medical inpatients admitted to non-intensive care unit: a prospective cohort study.BMC psychiatry · 2025Observational
- Prevalence of delirium in German nursing homes: protocol for a cross-sectional study.BMJ open · 2025Article
- The Reality of Physical Restraint Implementation During Hospitalization in Older Patients With Hip Fractures.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Delirium in Lower Limb Trauma: The Incidence and Risk Factors in a Prospective Observational Study.Indian journal of orthopaedics · 2024Article
- Clozapine-associated adverse drug reactions in 38,349 psychiatric inpatients: drug surveillance data from the AMSP project between 1993 and 2016.Journal of neural transmission (Vienna, Austria : 1996) · 2024Observational
- Effectiveness of antipsychotics for managing agitated delirium in patients with advanced cancer: a secondary analysis of a multicenter prospective observational study in Japan (Phase-R).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Delirium in Medically Hospitalized Patients: Prevalence, Recognition and Risk Factors: A Prospective Cohort Study.Journal of clinical medicine · 2023Article
- Early incident and subsyndromal delirium in older patients undergoing elective surgical procedures: a randomized clinical trial of an avoid delirium protocol.Frontiers in anesthesiology · 2023Article
- Association between smoking and postoperative delirium in surgical patients with pulmonary hypertension: a secondary analysis of a cohort study.BMC psychiatry · 2022Article
- Stratified delirium risk using prescription medication data in a state-wide cohort.General hospital psychiatryArticle
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the association between polypharmacy and the occurrence of delirium has been well studied, the influence of polypharmacy on the persistence of delirium remains unclear. We aimed to explore the effect of polypharmacy on the persistence of delirium.
methodsThis retrospective cohort study was conducted at a tertiary hospital. The medical records of patients diagnosed with delirium who were referred to the Department of Psychosomatic Medicine were reviewed. Presentation with delirium on day 3 was set as the outcome in this study. We counted the number of drugs prescribed on the date of referral, excluding general infusion fluids, nutritional or electrolytic products, and psychotropics. To define polypharmacy, we developed a classification and regression tree (CART) model and drew a receiver operating characteristic (ROC) curve. The odds ratio (OR) of polypharmacy for the persistence of delirium on day 3 was calculated using a logistic regression model with the propensity score as a covariate.
resultsWe reviewed the data of 113 patients. The CART model and ROC curve indicated an optimal polypharmacy cutoff of six drugs. Polypharmacy was significantly associated with the persistence of delirium both before [OR, 3.02; 95% confidence interval (CI), 1.39-6.81;
conclusionWe discovered an association between polypharmacy and worsening courses of delirium and hypothesize that polypharmacy might be a prognostic factor for delirium.
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