Evidence map›Paper›PMID 33042162›Full record

ArticleFrontiers in immunology2020

Eosinophils Control Liver Damage by Modulating Immune Responses Against

Sofía Frigerio, Valeria da Costa, Monique Costa, María Florencia Festari, Mercedes Landeira, Santiago A Rodríguez-Zraquia, Steffen Härtel, Jorge Toledo, Teresa Freire

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Liver Histopathological and Immunohistochemical Evaluation fromAnimals : an open access journal from MDPI · 2024
    Article
  4. Article
  5. An Update on the Pathogenesis of Fascioliasis: What Do We Know?Research and reports in tropical medicine · 2024
    Review
  6. Macrophage Gal/GalNAc lectin 2 (MGL2)Scientific reports · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Autonomous Non Antioxidant Roles forFrontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sofía FrigerioLaboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.
Valeria da CostaLaboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.
Monique CostaLaboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.
María Florencia FestariLaboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.
Mercedes LandeiraLaboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.
Santiago A Rodríguez-ZraquiaLaboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.
Steffen HärtelLaboratorio de Análisis Imágenes Científicas, SCIAN-lab, Instituto de Neurociencias Biomédicas (BNI), Facultad de Medicina Universidad de Chile, Santiago, Chile.
Jorge ToledoLaboratorio de Análisis Imágenes Científicas, SCIAN-lab, Instituto de Neurociencias Biomédicas (BNI), Facultad de Medicina Universidad de Chile, Santiago, Chile.
Teresa FreireLaboratorio de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay.
Universidad de la República · UYInstituto de Neurociencia Biomédica · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophils are granulocytes that participate in the defense against helminth parasites and in hypersensitivity reactions. More recently, eosinophils were shown to have other immunomodulatory functions, such as tissue reparation, metabolism regulation, and suppression of Th1 and Th17 immune responses. In the context of parasitic helminth infections, eosinophils have a controversial role, as they can be beneficial or detrimental for the host. In this work, we investigate the role of eosinophils in an experimental infection in mice with the trematode parasite

Indexed as

AnimalsAntibody-Dependent Cell CytotoxicityCD4-Positive T-LymphocytesCell DegranulationCells, CulturedChemokine CCL11Disease Models, AnimalEosinophilsFasciola hepaticaFascioliasisFemaleHost-Pathogen InteractionsHumansImmunomodulationInterleukin-10LiverChemokine CCL11Interleukin-10Sialic Acid Binding Immunoglobulin-like LectinsSiglecf protein, mouseantibodiesantibody-dependent cell cytotoxicitydegranulationeosinophilsFasciola hepaticaimmunomodulation

Identifiers

PMID33042162
PMCPMC7530260
OpenAlexW3087369050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.