Evidence map›Paper›PMID 33042140›Full record

ArticleFrontiers in immunology2020

Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans.

Gwendolyn M Swarbrick, Anele Gela, Meghan E Cansler, Megan D Null, Rowan B Duncan, Elisa Nemes, Muki Shey, Mary Nsereko, Harriet Mayanja-Kizza, Sarah Kiguli and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Gwendolyn M SwarbrickDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Anele GelaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Meghan E CanslerDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Megan D NullDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Rowan B DuncanDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Elisa NemesSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Muki SheySouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Mary NserekoUganda-CWRU Research Collaboration, Kampala, Uganda.
Harriet Mayanja-KizzaUganda-CWRU Research Collaboration, Kampala, Uganda.
Sarah KiguliUganda-CWRU Research Collaboration, Kampala, Uganda.
Jeffrey KohDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, United States.
Willem A HanekomSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Mark HatherillSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Christina LancioniDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
David M LewinsohnPortland Veterans Administration Healthcare System, Portland, OR, United States.
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Deborah A LewinsohnDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, United States.
Oregon Health & Science University · USSouth African Tuberculosis Vaccine Initiative · ZAInfectious Diseases Research Collaboration · UGUniversity of Cape Town · ZAMakerere University · UG

Funding

Host determinants of protection against tuberculosis in adolescentsR01AI087915 · NIAID · UNIVERSITY OF CAPE TOWN · PI SCRIBA, THOMAS JENS · 2011 to 2015
$3.3M
Protective immunity induced by newborn BCG vaccinationR01AI065653 · NIAID · UNIVERSITY OF CAPE TOWN · PI HANEKOM, WILLEM ALBERT · 2005 to 2009
$2.5M
Memory, Phenotype, and Function of TB-reactive Human MR1 Restricted T cellsR01AI129980 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., LEWINSOHN, DEBORAH A. · 2019 to 2022
$2.4M
The innate capacity of human T cells to respond to Mycobacterium tuberculosisR01AI104229 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DEBORAH A. · 2013 to 2016
$1.5M
NIAID NIH HHS HHSN272200900053CNIAID NIH HHS R01 AI065653NIAID NIH HHS R01 AI087915NIAID NIH HHS R01 AI104229NIAID NIH HHS R01 AI129980
6 · The paper itself

Abstract

MR1-restricted T (MR1T) cells are defined by their recognition of metabolite antigens presented by the monomorphic MHC class 1-related molecule, MR1, the most highly conserved MHC class I related molecule in mammalian species. Mucosal-associated invariant T (MAIT) cells are the predominant subset of MR1T cells expressing an invariant TCR α-chain, TRAV1-2. These cells comprise a T cell subset that recognizes and mediates host immune responses to a broad array of microbial pathogens, including

Indexed as

AdolescentChildChild, PreschoolHumansImmunity, InnateImmunity, MucosalImmunophenotypingInfantInfant, NewbornMucosal-Associated Invariant T CellsMucous MembraneMycobacterium bovisPhenotypeT-Lymphocyte SubsetsVaccinationhuman mucosal immunologyinfantinnate T cellsMAIT cellstuberculosis

Identifiers

PMID33042140
PMCPMC7524872
OpenAlexW3086230700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.