Evidence map›Paper›PMID 33042124›Full record

ArticleFrontiers in immunology2020

The TLR4-MyD88 Signaling Axis Regulates Lung Monocyte Differentiation Pathways in Response to

Rodrigo Sánchez-Tarjuelo, Isabel Cortegano, Juliana Manosalva, Mercedes Rodríguez, Carolina Ruíz, Mario Alía, María Carmen Prado, Eva M Cano, María José Ferrándiz, Adela G de la Campa and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026
    Review
  3. Article
  4. Neonatal CD19Frontiers in immunology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. A narrative review of chemokine receptors CXCR1 and CXCR2 and their role in acute respiratory distress syndrome.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Toll-Like Receptors in Acute Kidney Injury.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rodrigo Sánchez-TarjueloImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Isabel CorteganoImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Juliana ManosalvaImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Mercedes RodríguezImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Carolina RuízImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Mario AlíaImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
María Carmen PradoImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Eva M CanoChronic Disease Programme, Carlos III Health Institute, Madrid, Spain.
María José FerrándizBacterial Genetics Department, Carlos III Health Institute, Madrid, Spain.
Adela G de la CampaBacterial Genetics Department, Carlos III Health Institute, Madrid, Spain.
María Luisa GasparImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Belén de AndrésImmunobiology Department, Carlos III Health Institute, Madrid, Spain.
Instituto de Salud Carlos III · ESUnidades Centrales Científico-Técnicas · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Administration, IntranasalAnimalsBacterial LoadCytokinesImmunity, InnateLungMacrophages, AlveolarMiceMonocytesMyeloid Differentiation Factor 88MyelopoiesisNeutrophil InfiltrationPneumonia, PneumococcalReactive Oxygen SpeciesSignal TransductionStreptococcus pneumoniaeCytokinesMyd88 protein, mouseMyeloid Differentiation Factor 88Reactive Oxygen SpeciesTlr4 protein, mouseToll-Like Receptor 4innate immune responsesmonocyte differentiationMyD88ROSS. pneumoniaeTLR4

Identifiers

PMID33042124
PMCPMC7525032
OpenAlexW3085443025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.