Evidence map›Paper›PMID 33042119›Full record

ArticleFrontiers in immunology2020

Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig D

Mohamed Khass, Michael Levinson, Robert L Schelonka, Pratibha Kapoor, Peter D Burrows, Harry W Schroeder

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Replacement of TCR Dβ With Immunoglobulin DFrontiers in immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Mohamed KhassDivision of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Michael LevinsonDivision of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Robert L SchelonkaDivision of Neonatology, Department of Pediatrics, Oregon Health Science Center, Portland, OR, United States.
Pratibha KapoorDivision of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Peter D BurrowsDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Harry W SchroederDivision of Clinical Immunology and Rheumatology, Department of Medicine, Microbiology, and Genetics, The University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
HLA Region and KIR Genomics in Common Variable Immune DeficiencyU01AI090902 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHROEDER, HARRY WILLIAM · 2010 to 2014
$2.9M
Role of VpreB in immunoglobulin antigen binding site selectionR21AI134027 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHROEDER, HARRY WILLIAM · 2018 to 2019
$408k
The pre-BCR CDR-H3 sensing site and H chain selectionR21AI117703 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHROEDER, HARRY WILLIAM · 2015 to 2016
$404k
NIAID NIH HHS R21 AI117703NIAID NIH HHS R21 AI134027NIAID NIH HHS T32 AI007051NIAID NIH HHS U01 AI090902
6 · The paper itself

Abstract

We have previously shown that the sequence of the immunoglobulin diversity gene segment (D

Indexed as

AnimalsAntibody DiversityB-LymphocytesCells, CulturedComplementarity Determining RegionsGenetic EngineeringGenetic VariationGerm CellsImmunoglobulin DImmunoglobulin Heavy ChainsMiceMice, Inbred C57BLReceptors, Antigen, T-Cell, alpha-betaComplementarity Determining RegionsImmunoglobulin DImmunoglobulin Heavy ChainsReceptors, Antigen, T-Cell, alpha-betaD gene segmentgene segmentgermlineimmunoglobulinT cell receptor

Identifiers

PMID33042119
PMCPMC7518465
OpenAlexW3084498480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.