Evidence map›Paper›PMID 33042117›Full record

ArticleFrontiers in immunology2020

Astragalin Attenuates Dextran Sulfate Sodium (DSS)-Induced Acute Experimental Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting NF-κB Activation in Mice.

Lei Peng, Xiaoyu Gao, Long Nie, Jing Xie, Tianyi Dai, Chongying Shi, Liang Tao, Yan Wang, Yang Tian, Jun Sheng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Microbiota-derived indole limitsScience advances · 2026
    Article
  4. Article
  5. Protective Effect ofJournal of microbiology and biotechnology · 2026
    Article
  6. Astragaloside IV fromAntioxidants (Basel, Switzerland) · 2026
    Article
  7. International journal of molecular sciences · 2026
    Article
  8. Preventive Effects of Probiotic and PostbioticJournal of microbiology and biotechnology · 2026
    Article
  9. Article
  10. Optimization of dextran sulfate sodium-induced colitis and associated mortality in BALB/c mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lei PengEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, China.
Xiaoyu GaoEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, China.
Long NieCollege of Food Science and Technology, Yunnan Agricultural University, Kunming, China.
Jing XieEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, China.
Tianyi DaiEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, China.
Chongying ShiCollege of Food Science and Technology, Yunnan Agricultural University, Kunming, China.
Liang TaoEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, China.
Yan WangYunnan Provincial Key Laboratory of Biological Big Data, Yunnan Agricultural University, Kunming, China.
Yang TianEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, China.
Jun ShengYunnan Province Research Institute of Plateau Characteristic Agricultural Industry, Kunming, China.
Yunnan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the ulcerative colitis (UC) incidence increasing worldwide, it is of great importance to prevent and treat UC. However, efficient treatment options for UC are relatively limited. Due to the potentially serious adverse effects of existing drugs, there is an increasing demand for alternative candidate resources derived from natural and functional foods. Astragalin (AG) is a type of anti-inflammatory flavonoid, with

Indexed as

AnimalsAnti-Inflammatory AgentsColitisColonCytokinesDextran SulfateGastrointestinal MicrobiomeHumansInflammation MediatorsKaempferolsMaleMiceMice, Inbred C57BLModels, AnimalMucin-2NF-kappa BAnti-Inflammatory AgentsastragalinCytokinesDextran SulfateInflammation MediatorsKaempferolsMuc2 protein, mouseMucin-2NF-kappa BTjp1 protein, mouseZonula Occludens-1 ProteinAstragalinEscherichia-Shigellagut microbiotaNF-κBRuminococcaceaeulcerative colitis

Identifiers

PMID33042117
PMCPMC7523281
OpenAlexW3086793634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.