Evidence map›Paper›PMID 33042115›Full record

ArticleFrontiers in immunology2020

TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis.

Jinai Li, Can Cao, Yali Xiang, Zhongsi Hong, Duanman He, Haibo Zhong, Ye Liu, Yongjian Wu, Xiaobin Zheng, Huan Yin and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  7. The PE/PPE family proteins ofFrontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jinai LiCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Can CaoCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Yali XiangCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Zhongsi HongCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Duanman HeThe Third People's Hospital of Shantou, Shantou, China.
Haibo ZhongThe Third People's Hospital of Shantou, Shantou, China.
Ye LiuCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Yongjian WuCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Xiaobin ZhengCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Huan YinCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Jie ZhouFoshan Fourth People's Hospital, Foshan, China.
Hanbin XieThe Third People's Hospital of Shantou, Shantou, China.
Xi HuangCenter for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.
Sun Yat-sen University · CNFifth Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The function of triggering receptor expressed on myeloid cell-like transcript 2 (TLT2) has not been characterized and their role in pulmonary tuberculosis (TB) remains unclear. In this study, we found that surface TLT2 was up-regulated in human monocytes of patients with active TB compared to healthy subjects.

Indexed as

Signal TransductionAdultAnimalsBiomarkersFemaleGene ExpressionHost-Pathogen InteractionsHumansInterleukin-6Janus KinasesMaleMiceMiddle AgedMonocytesReceptors, ImmunologicSTAT3 Transcription FactorBiomarkersInterleukin-6Janus KinasesReceptors, ImmunologicSTAT3 protein, humanSTAT3 Transcription FactorTREML2 protein, humanIL-6monocyteSTAT3Th1TLT2Tuberculosis

Identifiers

PMID33042115
PMCPMC7516513
OpenAlexW3084765129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.