Evidence map›Paper›PMID 33041789›Full record

ArticleFrontiers in pharmacology2020

Design and Synthesis of Novel Nordihydroguaiaretic Acid (NDGA) Analogues as Potential FGFR1 Kinase Inhibitors With Anti-Gastric Activity and Chemosensitizing Effect.

Qian Chen, Min Zhu, Jingwen Xie, Zhaojun Dong, Fatehi Khushafah, Di Yun, Weitao Fu, Ledan Wang, Tao Wei, Zhiguo Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qian ChenThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Min ZhuChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Jingwen XieChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Zhaojun DongChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Fatehi KhushafahChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Di YunChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Weitao FuChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Ledan WangDepartment of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tao WeiChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Zhiguo LiuChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Peihong QiuChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Jianzhang WuChemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Wulan LiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant fibroblast growth factor receptor-1 (FGFR1), a key driver promoting gastric cancer (GC) progression and chemo-resistance, has been increasingly recognized as a potential therapeutic target in GC. Hereon, we designed and synthesized a series of asymmetric analogues using

Indexed as

chemosensitizing effectfibroblast growth factor receptor-1 inhibitorgastric cancernordihydroguaiaretic acid analoguessynthesis

Identifiers

PMID33041789
PMCPMC7517944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.