ArticleFrontiers in neuroscience2020
Paramagnetic Metal Accumulation in the Deep Gray Matter Nuclei Is Associated With Neurodegeneration in Wilson's Disease.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Distinctive Pattern of Metal Deposition in Neurologic Wilson Disease: Insights From 7T Susceptibility-Weighted Imaging.Neurology · 2024Article
- Wilson Disease: Copper-Mediated Cuproptosis, Iron-Related Ferroptosis, and Clinical Highlights, with Comprehensive and Critical Analysis Update.International journal of molecular sciences · 2024Review
- Evaluating iron deposition in gray matter nuclei of patients with acute ischemic stroke using quantitative susceptibility mapping.Frontiers in neurology · 2024Article
- Machine learning for detecting Wilson's disease by amplitude of low-frequency fluctuation.Heliyon · 2023Article
- Microstructural and functional impairment of the basal ganglia in Wilson's disease: a multimodal neuroimaging study.Frontiers in neuroscience · 2023Article
- Neuroimaging correlates of brain injury in Wilson's disease: a multimodal, whole-brain MRI study.Brain : a journal of neurology · 2022Article
- Increased Magnetic Susceptibility in the Deep Gray Matter Nuclei of Wilson's Disease: Have We Been Ignoring Atrophy?Frontiers in neuroscience · 2022Article
- Wilson's Disease: An Update on the Diagnostic Workup and Management.Journal of clinical medicine · 2021Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuropathological studies have revealed copper and iron accumulation in the deep gray matter (DGM) nuclei of patients with Wilson's disease (WD). However, the association between metal accumulation and neurodegeneration in WD has not been well studied
methodsSeventeen neurological WD patients and 20 healthy controls were recruited for the study. Mean bulk susceptibility values and volumes of DGM were obtained from quantitative susceptibility mapping (QSM). Regions of interest including the head of the caudate nucleus, globus pallidus, putamen, thalamus, substantia nigra, red nucleus, and dentate nucleus were manually segmented. The susceptibility values and volumes of DGM in different groups were compared using a linear regression model. Correlations between susceptibility values and volumes of DGM and Unified Wilson's Disease Rating Scale (UWDRS) neurological subscores were investigated.
resultsThe susceptibility values of all examined DGM in WD patients were higher than those in healthy controls (
conclusionOur study provided
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