Evidence map›Paper›PMID 33041755›Full record

ArticleFrontiers in neuroscience2020

Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping.

Shun Zhang, Junghun Cho, Thanh D Nguyen, Pascal Spincemaille, Ajay Gupta, Wenzhen Zhu, Yi Wang

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Brain oxygen extraction fraction mapping in patients with multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  8. Recent Advances in MR Imaging-based Quantification of Brain Oxygen Metabolism.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Brain oxygen extraction and neural tissue susceptibility are associated with cognitive impairment in older individuals.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shun ZhangDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Junghun ChoDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Thanh D NguyenDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Pascal SpincemailleDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Ajay GuptaDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yi WangDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.

Funding

Quantitative Mapping of Substantia Nigra Iron in Parkinson's DiseaseR01NS095562 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHTILBANS, ALEXANDER, WANG, YI · 2016 to 2022
$3.1M
Multiple Sclerosis Lesion Magnetic Susceptibility ActivityR01NS090464 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2015 to 2020
$2.3M
3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0M
Compact Representations of Dynamic Liver MRIR01CA181566 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SPINCEMAILLE, PASCAL · 2015 to 2019
$1.9M
Feasibility of challenge-free QSM based quantitative mapping of cerebral metabolic rate of oxygenR21EB024366 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI GOYAL, MANU S, SU, YI · 2017 to 2018
$474k
NCI NIH HHS R01 CA181566NIBIB NIH HHS R21 EB024366NIH HHS S10 OD021782NINDS NIH HHS R01 NS090464NINDS NIH HHS R01 NS095562
6 · The paper itself

Abstract

MRI-based oxygen extraction fraction imaging has a great potential benefit in the selection of clinical strategies for ischemic stroke patients. This study aimed to evaluate the performance of a challenge-free oxygen extraction fraction (OEF) mapping in a cohort of acute and subacute ischemic stroke patients. Consecutive ischemic stroke patients (a total of 30 with 5 in the acute stage, 19 in the early subacute stage, and 6 in the late subacute stage) were recruited. All subjects underwent MRI including multi-echo gradient echo (mGRE), diffusion weighted imaging (DWI), and 3D-arterial spin labeling (ASL). OEF maps were generated from mGRE phase + magnitude data, which were processed using quantitative susceptibility mapping (QSM) + quantitative blood oxygen level-dependent (qBOLD) imaging with cluster analysis of time evolution. Cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) maps were reconstructed from 3D-ASL and DWI, respectively. Further, cerebral metabolic rate of oxygen (CMRO

Indexed as

cerebral blood flowcerebral metabolic rate of oxygenischemic strokeMRIoxygen extraction fractionquantitative susceptibility mapping

Identifiers

PMID33041755
PMCPMC7525031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.