Evidence map›Paper›PMID 33041743›Full record

ArticleAdvanced functional materials2019

Biodegradable fluorescent nanoparticles for endoscopic detection of colorectal carcinogenesis.

Stephan Rogalla, Krzysztof Flisikowski, Dimitris Gorpas, Aaron T Mayer, Tatiana Flisikowska, Michael J Mandella, Xiaopeng Ma, Kerriann M Casey, Stephen A Felt, Dieter Saur and 5 more

Open access · greenAbstract read
In one paragraph

Article in Advanced functional materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

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  8. Pigs: Large Animal Preclinical Cancer Models.World journal of oncology · 2024
    Review
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  10. TNF ΔARE Pigs: A Translational Crohn's Disease Model.Journal of Crohn's & colitis · 2023
    Article
  11. A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Stephan RogallaMolecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Krzysztof FlisikowskiChair of Livestock Biotechnology, Technische Universität München, Liesel-Beckmann Str. 1, D-85354 Freising, Germany.
Dimitris GorpasHelmholtz Zentrum München, German Researcg Center for Environmental Health, Institute of Biological and Medical Imaging, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.
Aaron T MayerMolecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tatiana FlisikowskaChair of Livestock Biotechnology, Technische Universität München, Liesel-Beckmann Str. 1, D-85354 Freising, Germany.
Michael J MandellaMolecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Xiaopeng MaHelmholtz Zentrum München, German Researcg Center for Environmental Health, Institute of Biological and Medical Imaging, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.
Kerriann M CaseyDepartment of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stephen A FeltDepartment of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Dieter SaurDepartment of Internal Medicine II, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany.
Vasilis NtziachristosHelmholtz Zentrum München, German Researcg Center for Environmental Health, Institute of Biological and Medical Imaging, Ingolstädter Landstr. 1, D-85764, Neuherberg, Germany.
Angelika SchniekeChair of Livestock Biotechnology, Technische Universität München, Liesel-Beckmann Str. 1, D-85354 Freising, Germany.
Christopher H ContagInstitute for Quantitative Health Science and Engineering, Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, MI 48824, USA.
Sanjiv S GambhirMolecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stefan HarmsenMolecular Imaging Program at Stanford University (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USHelmholtz Zentrum München · DETechnical University of Munich · DEMichigan State University · USGerman Cancer Research Center · DEStanford Medicine · US

Funding

Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI SINCLAIR, ROBERT · 2015 to 2019
$9.6M
Raman Molecular Imaging for Early Detection of Colon CancerR01CA182043 · NCI · STANFORD UNIVERSITY · PI CONTAG, CHRISTOPHER H · 2015 to 2020
$2.8M
NCI NIH HHS R01 CA182043NCI NIH HHS U54 CA199075
6 · The paper itself

Abstract

Early and comprehensive endoscopic detection of colonic dysplasia - the most clinically significant precursor lesion to colorectal adenocarcinoma - provides an opportunity for timely, minimally-invasive intervention to prevent malignant transformation. Here, the development and evaluation of biodegradable near-infrared fluorescent silica nanoparticles (FSN) is described that have the potential to improve adenoma detection during fluorescence-assisted white-light colonoscopic surveillance in rodent and human-scale models of colorectal carcinogenesis. FSNs are biodegradable (t

Indexed as

Biodegradablecolorectal lesionsendoscopyfluorescent nanoparticlesimaging

Identifiers

PMID33041743
PMCPMC7546531
OpenAlexW2979575963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.