Evidence map›Paper›PMID 33041740›Full record

ArticleAdvanced functional materials2017

Covalently adaptable elastin-like protein - hyaluronic acid (ELP - HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery.

Huiyuan Wang, Danqing Zhu, Alexandra Paul, Lei Cai, Annika Enejder, Fan Yang, Sarah C Heilshorn

Open access · greenAbstract read
In one paragraph

Article in Advanced functional materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 271 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. On-Demand Chemically Degradable Hydrogels for Biological Applications.Chembiochem : a European journal of chemical biology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Submucosal Hydrogel for Spring-Mediated Intestinal Lengthening.Journal of biomedical materials research. Part A · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  19. Advancing Synthetic Hydrogels through Nature-Inspired Materials Chemistry.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  20. Cell-Material Interactions in Covalent Adaptable Thioester Hydrogels.ACS biomaterials science & engineering · 2024
    Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Huiyuan WangDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, 94305, USA.
Danqing ZhuDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Alexandra PaulDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden.
Lei CaiDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, 94305, USA.
Annika EnejderDepartment of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden.
Fan YangDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Sarah C HeilshornDepartment of Materials Science & Engineering, Stanford University, Stanford, CA, 94305, USA.
Stanford University · USChalmers University of Technology · SE

Funding

Stanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI BARIC, RALPH S · 2015 to 2025
$13.5M
Microribbon scaffold-mediated Immunomodulation for Cranial Bone RepairR01DE024772 · NIDCR · STANFORD UNIVERSITY · PI YANG, FAN · 2015 to 2025
$4.6M
Engineered Intestinal Microenvironments as Preclinical Drug Screening PlatformsR21EB018407 · NIBIB · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C · 2014 to 2015
$427k
NIAID NIH HHS U19 AI116484NIBIB NIH HHS R21 EB018407NIDCR NIH HHS R01 DE024772
6 · The paper itself

Abstract

Shear-thinning, self-healing hydrogels are promising vehicles for therapeutic cargo delivery due to their ability to be injected using minimally invasive surgical procedures. We present an injectable hydrogel using a novel combination of dynamic covalent crosslinking with thermoresponsive engineered proteins.

Indexed as

dynamic covalent chemistryelastin-like protein (ELP)injectable hydrogelmesenchymal stem cellsecondary crosslinking

Identifiers

PMID33041740
PMCPMC7546546
OpenAlexW2616230715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.