Evidence map›Paper›PMID 33041703›Full record

ArticleIntegrative medicine (Encinitas, Calif.)2020

Efficacy of Spore Forming Bacilli Supplementation in Patients with Mild to Moderate Elevation of Triglycerides: A 12 week, Randomized, Double-Blind, Placebo Controlled Trial.

Andrew W Campbell, Drew Sinatra, Zhiwei Zhang, Stephen T Sinatra

Open access · greenAbstract read
In one paragraph

Article in Integrative medicine (Encinitas, Calif.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The Effects of ProbioticInternational journal of molecular sciences · 2023
    Article
  3. Potential application of the probioticFrontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Andrew W CampbellMedical Director of Mymycolab in Land O Lakes, Florida.
Drew Sinatranaturopathic doctor of integrative medicine at the CLEAR Center for Health in Mill Valley, California.
Zhiwei ZhangDepartment of Statistics-University of California Riverside, in Riverside California.
Stephen T Sinatraassistant clinical professor of medicine at the School of Medicine, University of Connecticut in Farmington, Connecticut.
Mill Valley Public Library · USMyriad (Germany) · DEUniversity of California, Riverside · USUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this randomized double-blind placebo controlled clinical trial was to evaluate the effects of a commercial spore-based probiotic supplement consisting of 5 different spore forming bacilli ( STUDY

designA randomized, double-blind, placebo-controlled study with eighty participants with non-fasting triglyceride levels greater than 150 mg/dL.

methodsEighty participants with non-fasting triglyceride levels greater than 150 mg/dL were randomized to receive oral probiotic supplement consisting of two capsules containing 5 different spore forming bacilli once daily in the morning or a placebo (rice flour). Their non-fasting triglyceride levels were measured again at six weeks and at twelve weeks.

resultsCompared to the placebo group, participants in the probiotic supplement group had significant lowering of their triglyceride levels after 90 days.

conclusionMild to moderately elevated triglyceride levels can be lowered in patients with mild to moderate HT by a probiotic supplement consisting of five different spore forming bacilli.

Identifiers

PMID33041703
PMCPMC7482325
OpenAlexW3092494956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.