Evidence map›Paper›PMID 33041613›Full record

ArticleJournal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America2020

A stochastic second-order generalized estimating equations approach for estimating association parameters.

Tom Chen, Eric J Tchetgen Tchetgen, Rui Wang

Abstract read
In one paragraph

Article in Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Variable selection in modelling clustered data via within-cluster resampling.The Canadian journal of statistics = Revue canadienne de statistique · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tom ChenDepartment of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School.
Eric J Tchetgen TchetgenDepartment of Statistics, The Wharton School, The University of Pennsylvania.
Rui WangDepartment of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School.

Funding

GRADUATE TRAINING IN BIOSTATISTICST32ES007142 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$11.9M
Methods to Advance the HIV Prevention Research AgendaR37AI051164 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEGRUTTOLA, VICTOR GERARD · 2012 to 2019
$3.3M
Next Generation Missing Data Methods in HIV ResearchR01AI127271 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TCHETGEN TCHETGEN, ERIC JOEL · 2017 to 2021
$3.2M
Theory and methods for mediation and interactionR01CA222147 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL, VANDERWEELE, TYLER · 2018 to 2022
$2.1M
Network modeling and robust estimation of the intraclass correlation coefficient to inform the design and analysis of cluster randomized trials for infectious diseasesR01AI136947 · NIAID · HARVARD PILGRIM HEALTH CARE, INC. · PI WANG, RUI · 2018 to 2020
$759k
NCI NIH HHS R01 CA222147NIAID NIH HHS R01 AI127271NIAID NIH HHS R01 AI136947NIAID NIH HHS R37 AI051164NIEHS NIH HHS T32 ES007142
6 · The paper itself

Abstract

Design and analysis of cluster randomized trials must take into account the intraclass correlation coefficient (ICC), which quantifies the correlation among outcomes from the same cluster. Second-order generalized estimating equations (GEE2) provides a statistically robust way in estimating this quantity and other association parameters. However, GEE2 becomes computationally infeasible as cluster sizes grow. This paper proposes a stochastic variant to fitting GEE2 which alleviates reliance on parameter starting values and provides substantially faster speeds and higher convergence rates than the widely used deterministic Newton-Raphson method. We also propose new estimators for the ICC which account for informative missing outcome data through the use of GEE2, for which we incorporate a "second-order" inverse probability weighting scheme and "second-order" doubly robust (DR) estimating equations that guard against partial model misspecification. Our proposed methods are evaluated through simulations and applied to data from a cluster randomized trial in Bangladesh evaluating the effect of different marketing interventions on the use of hygienic latrines.

Indexed as

Clustered datadoubly robustGEE2Robbins-Monro

Identifiers

PMID33041613
PMCPMC7540735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.