ArticleJournal of clinical biochemistry and nutrition2020
Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome.
Article in Journal of clinical biochemistry and nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- HMolecular and cellular biochemistry · 2026Review
- Article
- Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review.International journal of molecular sciences · 2025Review
- Hydrogen gas inhalation therapy may not work sufficiently to mitigate oxidative stress induced with REBOA.Scientific reports · 2024Article
- Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study.Biomedicines · 2024Article
- Article
- Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues.Journal of stroke · 2024Review
- Mechanisms and treatment of anemia related to cardiac arrest.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.International journal of medical sciences · 2024Observational
- Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes.Molecules (Basel, Switzerland) · 2023Review
- Hydrogen Therapy and Its Future Prospects for Ameliorating COVID-19: Clinical Applications, Efficacy, and Modality.Biomedicines · 2023Review
- Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application.Cellular and molecular life sciences : CMLS · 2023Review
- Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients.Journal of clinical biochemistry and nutrition · 2023Article
- Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study.Frontiers in nutrition · 2023Article
- Neutrophils and Neutrophil Extracellular Traps in Cardiovascular Disease: An Overview and Potential Therapeutic Approaches.Biomedicines · 2022Review
- Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality?International journal of molecular sciences · 2022Review
- Article
- A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss.Frontiers in neuroscience · 2022Article
- Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing.Oncology reports · 2021Article
- Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress plays a key role in the pathophysiology of post-cardiac arrest syndrome. Molecular hydrogen reduces oxidative stress and exerts anti-inflammatory effects in an animal model of cardiac arrest. However, its effect on human post-cardiac arrest syndrome is unclear. We consecutively enrolled five comatose post-cardiac arrest patients (three males; mean age, 65 ± 15 years; four cardiogenic, one septic cardiac arrest) and evaluated temporal changes in oxidative stress markers and cytokines with inhaled hydrogen. All patients were treated with target temperature management. Hydrogen gas inhalation (2% hydrogen with titrated oxygen) was initiated upon admission for 18 h. Blood hydrogen concentrations, plasma and urine oxidative stress markers (derivatives of reactive oxygen metabolites, biological antioxidant potential, 8-hydroxy-2'-deoxyguanosine,
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