ArticleMedical archives (Sarajevo, Bosnia and Herzegovina)2020
"Second-look" Micro Testicular Sperm Extraction (MicroTESE) in Patients with Non-obstructive Azoospermia Following Histopathological Analysis.
Article in Medical archives (Sarajevo, Bosnia and Herzegovina), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Seminal long non-coding RNAs as prognostic non-invasive biomarkers in non-obstructive azoospermia.BMC medical genomics · 2026Article
- Second chance in fertility: a comprehensive narrative review of redo micro-TESE outcomes after initial failure.Asian journal of andrology · 2025Review
- Exploratory insights into histopathological patterns and repeat micro-TESE outcomes in non-obstructive azoospermia: a retrospective single-center study.Archives of medical science : AMS · 2025Article
- Testicular ultrasonic microvascular density in assessing spermatogenesis and predicting successful sperm retrieval.Quantitative imaging in medicine and surgery · 2024Article
- The relationship of testicular stiffness with Johnsen score and sperm retrieval outcome in men with non-obstructive azoospermia.Quantitative imaging in medicine and surgery · 2024Article
- Can We Predict the Outcome of Micro Testicular Sperm Extraction in Non-Obstructive Azoospermia From Preoperative Hormonal Profile, Testicular Volume, and Patients Health Factors: A Retrospective Cross-Sectional Study.American journal of men's healthArticle
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7 authors at 1 institution in 1 country.
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Abstract
introductionMicrodissection testicular sperm extraction (microTESE) is considered the gold standard method for surgical sperm retrieval among patients with non-obstructive azoospermia (NOA).
aimThis study aimed to evaluate the correlation between histopathological findings after failed microTESE procedure and outcomes of the "second-look" procedure and to provide insight into the most common histopathological patterns after testicular biopsy within our population.
methodsThe retrospective study included 33 selected patients with NOA, who had undergone unsuccessful sperm retrieval. The diagnosis of NOA was made after the assessment of the patient's history data, a physical examination, semen analysis, the hormonal profile, and genetic studies. After negative sperm retrieval, histopathological report has been analyzed for "second-look" microTESE attempt.
resultsFive testicular histopathological patterns were found: hypospermatogenesis (9,1%), Sertoli cell-only syndrome (43%), germ cell maturation arrest (15%), seminiferous tubule hyalinization (15%), mixed pattern (21%). Y-microdeletions were detected in 5 patients, of which 3 patients showed AZFc region deletions. Only 3 patients (9,1%) underwent a "second-look" procedure after the evaluation of histopathological reports. After the stimulation therapy and "second-look" procedure, we had a positive outcome in a single patient (33,3%). Mean FSH value in patients with confirmed spermatogenesis was 17.26±3.11IU/l, while mean FSH value in patients without presence or germ cell statistically significantly exceeded and was 24.28±4.71IU/L (p=0.038).
conclusionHistopathological reports following the microTESE procedure are obligatory for the proper selection of patients who are candidates for the "second-look" microTESE attempt. Patients with Sertoli cell-only syndrome and hypospermatogenesis particularly can benefit from the "second-look" procedure.
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