Evidence map›Paper›PMID 33041248›Full record

ReviewBiomedical journal2021

Immunotherapy in older patients with cancer.

C Granier, A Gey, S Roncelin, L Weiss, E Paillaud, E Tartour

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
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  6. Article
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  8. Review
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  14. CD57Immunity & ageing : I & A · 2024
    Article
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  16. Review
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  18. Review
  19. Article
  20. Increased levels of GM-CSF and CXCL10 and low CD8Immunity & ageing : I & A · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

C GranierBiological Immunology Department, APHP, Georges Pompidou European Hospital, Paris, France; University of Paris, PARCC, INSERM, APHP, Paris, France; Ligue Contre le Cancer Labeled Team, France. Electronic address: clemence.granier@aphp.fr.
A GeyBiological Immunology Department, APHP, Georges Pompidou European Hospital, Paris, France; University of Paris, PARCC, INSERM, APHP, Paris, France; Ligue Contre le Cancer Labeled Team, France.
S RoncelinBiological Immunology Department, APHP, Georges Pompidou European Hospital, Paris, France.
L WeissClinical Immunology Department, APHP, Paris, France; INSERM U976 HIPI, Paris, France; Paris Descartes Medical School, University of Paris, Paris, France.
E PaillaudDepartment of Geriatric, APHP, Paris Cancer Institute CARPEM, Europeen Georges Pompidou Hospital, Paris, France; Paris Est Creteil University, INSERM, IMRB, Creteil, France.
E TartourBiological Immunology Department, APHP, Georges Pompidou European Hospital, Paris, France; University of Paris, PARCC, INSERM, APHP, Paris, France; Ligue Contre le Cancer Labeled Team, France.
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRDélégation Paris 5 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing implicates a remodeling of our immune system, which is a consequence of the physiological senescence of our cells and tissues coupled with environmental factors and chronic antigen exposure. An immune system that senesces includes more differentiated cells with accumulation of highly differentiated CD4 and CD8 T cells. The pool of naive T cells decreases with the exponential thymic involution induced by age. Differentiated T cells have similar, if not higher, functional capacities but scarce studies are looking at the impact of senescence among specific T cells. After a stimulation, other immune cells (monocytes, dendritic cells and NK) are functionally altered during ageing. It is as if the immune system was more efficient at the basal level, but less efficient after a stimulation in the old compared to young people, likely due to less reserve. Concerning the clinical impact, older people are more prone to certain pathogens and their clinical manifestations differ from the younger people. Severe flu and VZV reactivation are more frequent with an altered cellular response to vaccination. Vaccination failure can have detrimental consequences in people presenting frailty criteria. Old people frailty is majored by their comorbidities and diseases like cancer. Thus, chemotherapies are employed with circumspection in older patients. The use of anti-PD-1/PD-L1 immunotherapies is therefore attractive, because of less side effects with a better response compared to chemotherapy. Old persons inclusion is lacking in current studies and clinical trials. Some subgroups or pooled analyses confirm the gain in response without increased toxicities in older patients but their inclusion criteria differ from the real-life practice. Specific studies focusing on this population are needed because of the increasing cancer incidence with age and the overall ageing of the population.

Indexed as

ImmunotherapyNeoplasmsAdolescentAgedAgingCD8-Positive T-LymphocytesHumansImmunologic FactorsImmunologic FactorsAgeingCancerElderlyImmunosenescenceImmunotherapyOld peopleOncogeriatry

Identifiers

PMID33041248
PMCPMC8358190
OpenAlexW3044620903

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.