Evidence map›Paper›PMID 33041122›Full record

ArticleThe American journal of emergency medicine2021

The disutility of stress testing in low-risk HEART Pathway patients.

Nicklaus P Ashburn, Zachary P Smith, Kale J Hunter, Nella W Hendley, Simon A Mahler, Brian C Hiestand, Jason P Stopyra

Abstract read
In one paragraph

Article in The American journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Rural and socioeconomic differences in the effectiveness of the HEART Pathway accelerated diagnostic protocol.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023
    Article
  3. Major adverse cardiac event rates in moderate-risk patients: Does prior coronary disease matter?Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022
    Article
  4. Contemporary Biomarker Strategies for Patients with Chest Pain.Reviews in cardiovascular medicine · 2022
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicklaus P AshburnDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States. Electronic address: n.ashburn@wakehealth.edu.
Zachary P SmithDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States.
Kale J HunterDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States.
Nella W HendleyDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States.
Simon A MahlerDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States; Departments of Epidemiology and Prevention and Implementation Science, Wake Forest School of Medicine, Winston Salem, NC, United States.
Brian C HiestandDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States.
Jason P StopyraDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States.

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
CVD Epidemiology Training ProgramT32HL076132 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAVID McLeod HERRINGTON · 2004 to 2026
$8.4M
Wake Forest Clinical and Translational Science AwardKL2TR001421 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MILLER, DAVID P · 2015 to 2023
$5.8M
NCATS NIH HHS KL2 TR001421NCATS NIH HHS UL1 TR001420NHLBI NIH HHS T32 HL076132
6 · The paper itself

Abstract

backgroundThe HEART Pathway identifies low-risk chest pain patients for discharge from the Emergency Department without stress testing. However, HEART Pathway recommendations are not always followed. The objective of this study is to determine the frequency and diagnostic yield of stress testing among low-risk patients.

methodsAn academic hospital's chest pain registry was analyzed for low-risk HEART Pathway patients (HEAR score ≤ 3 with non-elevated troponins) from 1/2017 to 7/2018. Stress tests were reviewed for inducible ischemia. Diagnostic yield was defined as the rate of obstructive CAD among patients with positive stress testing. T-test or Fisher's exact test was used to test the univariate association of age, sex, race/ethnicity, and HEAR score with stress testing. Multivariate logistic regression was used to determine the association of age, sex, race/ethnicity, and HEAR score with stress testing.

resultsThere were 4743 HEART Pathway assessments, with 43.7% (2074/4743) being low-risk. Stress testing was performed on 4.1% (84/2074). Of the 84 low-risk patients who underwent testing, 8.3% (7/84) had non-diagnostic studies and 2.6% (2/84) had positive studies. Among the 2 patients with positive studies, angiography revealed that 1 had widely patent coronary arteries and the other had multivessel obstructive coronary artery disease, making the diagnostic yield of stress testing 1.2% (1/84). Each one-point increase in HEAR score (aOR 2.17, 95% CI 1.45-3.24) and being male (aOR 1.59, 95% CI 1.02-2.49) were associated with testing.

conclusionsStress testing among low-risk HEART Pathway patients was uncommon, low yield, and more likely in males and those with a higher HEAR score.

Indexed as

Emergency Service, HospitalExercise TestAcute Coronary SyndromeChest PainDecision Support TechniquesFemaleGuideline AdherenceHumansMaleMiddle AgedRegistriesAccelerated diagnostic protocolAcute coronary syndrome (ACS)Chest painHEAR scoreHEART PathwayRisk stratificationStress testing

Identifiers

PMID33041122
PMCPMC8962568

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.