ArticleInfection control and hospital epidemiology2021
Scalable in-hospital decontamination of N95 filtering face-piece respirator with a peracetic acid room disinfection system.
Article in Infection control and hospital epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Decontaminating N95/FFP2 masks for reuse during the COVID-19 epidemic: a systematic review.Antimicrobial resistance and infection control · 2021Pooled it
- The COVID-19 pandemic and N95 masks: reusability and decontamination methods.Antimicrobial resistance and infection control · 2021Pooled it
- Efficacy and safety of disinfectants for decontamination of N95 and SN95 filtering facepiece respirators: a systematic review.The Journal of hospital infection · 2020Pooled it
- Evaluating the effects of air disinfectants in decontamination of COVID-19 aerosols.Health science reports · 2023Article
- Article
- Supercritical COThe Science of the total environment · 2022Article
- Review of aerosolized hydrogen peroxide, vaporized hydrogen peroxide, and hydrogen peroxide gas plasma in the decontamination of filtering facepiece respirators.American journal of infection control · 2022Review
- Corrigendum: Fogging With Peracetic Acid in Schools and Kindergartens.Frontiers in public health · 2022Article
- Evaluation of supercritical COThe Science of the total environment · 2021Article
- Decontamination of common healthcare facility surfaces contaminated with SARS-CoV-2 using peracetic acid dry fogging.The Journal of hospital infection · 2021Article
- Reprocessing of N95 masks: Experience from a resource-limited setting in India.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Evaluation of No-Touch Technologies for Decontamination of Toys in Pediatric Healthcare Settings.Open forum infectious diseases · 2021Article
- Fogging With Peracetic Acid in Schools and Kindergartens.Frontiers in public health · 2021Article
- Decontamination of N95 respirators against SARS-CoV-2: A scoping review.Journal of dentistry · 2021Article
- Tailoring surface wettability to reduce chances of infection of COVID-19 by a respiratory droplet and to improve the effectiveness of personal protection equipment.Physics of fluids (Woodbury, N.Y. : 1994) · 2020Article
- Measurement of filtration efficiencies of healthcare and consumer materials using modified respirator fit tester setup.PloS one · 2020Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCritical shortages of personal protective equipment, especially N95 respirators, during the coronavirus disease 2019 (COVID-19) pandemic continues to be a source of concern. Novel methods of N95 filtering face-piece respirator decontamination that can be scaled-up for in-hospital use can help address this concern and keep healthcare workers (HCWs) safe.
methodsA multidisciplinary pragmatic study was conducted to evaluate the use of an ultrasonic room high-level disinfection system (HLDS) that generates aerosolized peracetic acid (PAA) and hydrogen peroxide for decontamination of large numbers of N95 respirators. A cycle duration that consistently achieved disinfection of N95 respirators (defined as ≥6 log10 reductions in bacteriophage MS2 and Geobacillus stearothermophilus spores inoculated onto respirators) was identified. The treated masks were assessed for changes to their hydrophobicity, material structure, strap elasticity, and filtration efficiency. PAA and hydrogen peroxide off-gassing from treated masks were also assessed.
resultsThe PAA room HLDS was effective for disinfection of bacteriophage MS2 and G. stearothermophilus spores on respirators in a 2,447 cubic-foot (69.6 cubic-meter) room with an aerosol deployment time of 16 minutes and a dwell time of 32 minutes. The total cycle time was 1 hour and 16 minutes. After 5 treatment cycles, no adverse effects were detected on filtration efficiency, structural integrity, or strap elasticity. There was no detectable off-gassing of PAA and hydrogen peroxide from the treated masks at 20 and 60 minutes after the disinfection cycle, respectively.
conclusionThe PAA room disinfection system provides a rapidly scalable solution for in-hospital decontamination of large numbers of N95 respirators during the COVID-19 pandemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.