Evidence map›Paper›PMID 33040664›Full record

ArticleCognitive neuroscience

Structural variation within the left globus pallidus is associated with task-switching, not stimulus updating or distractor filtering.

George Zacharopoulos, Torkel Klingberg, Roi Cohen Kadosh

Abstract read
In one paragraph

Article in Cognitive neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Dissecting the neurocomputational bases of patch-switching.Cerebral cortex (New York, N.Y. : 1991) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George ZacharopoulosWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford , Oxford, UK.
Torkel KlingbergDepartment of Neuroscience, Karolinska Institute , Stockholm, Sweden.
Roi Cohen KadoshWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford , Oxford, UK.

Funding

Wellcome TrustWellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

Cognitive control is a pivotal aspect of cognition and it is impaired in many clinical populations. To date, several distinct types of cognitive control have been proposed, and prior work demonstrated the instrumental role of basal ganglia, frontal and parietal regions. However, the role of the structural variation of these regions in cognitive control functions is poorly understood. Here, we examined in 39 adults the association between regional brain volume and three major types of cognitive control: (i) stimulus updating, (ii) task-switching, and (iii) distractor filtering. The volume of the globus pallidus was positively correlated with individual variation in task-switching , and was anatomically specific to the left hemisphere. Importantly, this region did not track performance in distractor filtering or stimulus updating. We then aimed to use transcranial direct current stimulation to target the left midline subcortical structures. However, we did not find an effect on task-switching. While the null effect in the brain stimulation prevents us from drawing causal inference from the role of globus pallidus on task-switching, our structural results reveal a novel and highly specific neurostructural mechanism for task-switching and provide a further understanding of the link between cognitive control functions and the human brain.

Indexed as

AdultAttentionExecutive FunctionFemaleFunctional LateralityGlobus PallidusHumansMagnetic Resonance ImagingMaleMemory, Short-TermMiddle AgedPlacebosPrefrontal CortexPsychomotor PerformanceTranscranial Direct Current StimulationYoung AdultPlacebosglobus pallidustask-switchingWorking-memory

Identifiers

PMID33040664
PMCPMC7657600

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.