Evidence map›Paper›PMID 33040646›Full record

ArticleCirculation research2020

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells.

Redouane Aherrahrou, Liang Guo, V Peter Nagraj, Aaron Aguhob, Jameson Hinkle, Lisa Chen, Joon Yuhl Soh, Dillon Lue, Gabriel F Alencar, Arjan Boltjes and 18 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 8 institutions in 4 countries.

Redouane AherrahrouCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Liang GuoCVPath Institute, Inc, Gaithersburg, MD (L.G., D.F., A.F.).
V Peter NagrajSchool of Medicine Research Computing (V.P.N.), University of Virginia, Charlottesville.
Aaron AguhobCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Jameson HinkleCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Lisa ChenCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Joon Yuhl SohCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Dillon LueCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Gabriel F AlencarMolecular Physiology, Biological Physics, Medicine, Division of Cardiology, Robert M. Berne Cardiovascular Research Center (G.F.A., G.K.O.), University of Virginia, Charlottesville.
Arjan BoltjesLaboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, University of Utrecht (A.B., S.W.v.d.L., G.P.).
Sander W van der LaanLaboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, University of Utrecht (A.B., S.W.v.d.L., G.P.).
Emily FarberCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Daniela FullerCVPath Institute, Inc, Gaithersburg, MD (L.G., D.F., A.F.).
Rita Anane-WaeCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Ngozi AkingbesoteCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Ani W ManichaikulCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Lijiang MaGenetics and Genomic Sciences (L.M., J.L.M.B.), Icahn School of Medicine at Mount Sinai, NY.
Minna U KaikkonenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland (M.U.K.).
Johan L M BjörkegrenGenetics and Genomic Sciences (L.M., J.L.M.B.), Icahn School of Medicine at Mount Sinai, NY.
Suna Önengüt-GümüşcüCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Gerard PasterkampLaboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, University of Utrecht (A.B., S.W.v.d.L., G.P.).
Clint L MillerCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Gary K OwensMolecular Physiology, Biological Physics, Medicine, Division of Cardiology, Robert M. Berne Cardiovascular Research Center (G.F.A., G.K.O.), University of Virginia, Charlottesville.
Aloke FinnCVPath Institute, Inc, Gaithersburg, MD (L.G., D.F., A.F.).
Mohamad NavabMedicine, David Geffen School of Medicine, University of California, Los Angeles (M.N., A.M.F., J.A.B.).
Alan M FogelmanMedicine, David Geffen School of Medicine, University of California, Los Angeles (M.N., A.M.F., J.A.B.).
Judith A BerlinerMedicine, David Geffen School of Medicine, University of California, Los Angeles (M.N., A.M.F., J.A.B.).
Mete CivelekCenter for Public Health Genomics (R.A., A.A., J.H., L.C., J.Y.S., D.L., E.F., R.A.-W., N.A., A.W.M., S.O.-G., C.L.M., M.C.), University of Virginia, Charlottesville.
Anna Needs Neuroblastoma Answers · USCVPath Institute · USUniversity of California, Los Angeles · USUniversity of Virginia · USUtrecht University · NLIcahn School of Medicine at Mount Sinai · USIntegrated Cardio Metabolic Centre · SEUniversity of Eastern Finland · FI

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Multimodal genetic regulatory architecture of coronary artery diseaseR01HL148239 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint L Miller · 2019 to 2026
$4.2M
Defining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0M
Functional Characterization of Coronary Artery Disease LociR21HL135230 · NHLBI · UNIVERSITY OF VIRGINIA · PI CIVELEK, METE, GUERTIN, MICHAEL JOSEPH · 2018 to 2019
$242k
NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL148239NHLBI NIH HHS R21 HL135230
6 · The paper itself

Abstract

rationaleCoronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Recent genome-wide association studies revealed 163 loci associated with CAD. However, the precise molecular mechanisms by which the majority of these loci increase CAD risk are not known. Vascular smooth muscle cells (VSMCs) are critical in the development of CAD. They can play either beneficial or detrimental roles in lesion pathogenesis, depending on the nature of their phenotypic changes.

objectiveTo identify genetic variants associated with atherosclerosis-relevant phenotypes in VSMCs. METHODS AND

resultsWe quantified 12 atherosclerosis-relevant phenotypes related to calcification, proliferation, and migration in VSMCs isolated from 151 multiethnic heart transplant donors. After genotyping and imputation, we performed association mapping using 6.3 million genetic variants. We demonstrated significant variations in calcification, proliferation, and migration. These phenotypes were not correlated with each other. We performed genome-wide association studies for 12 atherosclerosis-relevant phenotypes and identified 4 genome-wide significant loci associated with at least one VSMC phenotype. We overlapped the previously identified CAD loci with our data set and found nominally significant associations at 79 loci. One of them was the chromosome 1q41 locus, which harbors

conclusionsOur data demonstrate that genetic variants have significant influences on VSMC function relevant to the development of atherosclerosis. Furthermore, high

Indexed as

Genetic VariationPlaque, AtheroscleroticAnimalsAryl Hydrocarbon Receptor Nuclear TranslocatorAtherosclerosisCell MovementCell ProliferationCells, CulturedDisease Models, AnimalFemaleFibrosisGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMice, Knockout, ApoEARNT protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorTANGO protein, mousecell proliferationcoronary artery diseasegenome-wide association studyhuman genetics

Identifiers

PMID33040646
PMCPMC7718324
OpenAlexW3092419740

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.