Evidence map›Paper›PMID 33040621›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1).

Liang Zhao, Xiaoyun Cao, Lingli Li, Xiaohua Wang, Qin Wang, Shan Jiang, Chun Tang, Suhan Zhou, Nan Xu, Yu Cui and 13 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 3 countries.

Liang ZhaoFrom the Department of Physiology, School of Basic Medical Sciences (L.Z., E.Y.L.), Guangzhou Medical University, China.
Xiaoyun CaoDepartment of Physiology, School of Basic Medical Sciences (L.Z., XG., Q. Wang, S.J., S.Z., N.X., Y.C., W.H., E.Y.L.), Zhejiang University School of Medicine, Hangzhou, China.
Lingli LiDivision of Nephrology and Hypertension (L.L., C.S.W., E.Y.L.), Georgetown University, Washington, DC.
Xiaohua WangDepartment of Nephrology, Center of Nephrology and Urology. the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China (X.W., C.T., L.F., Z.Z.).
Qin WangDepartment of Physiology, School of Basic Medical Sciences (L.Z., XG., Q. Wang, S.J., S.Z., N.X., Y.C., W.H., E.Y.L.), Zhejiang University School of Medicine, Hangzhou, China.
Shan JiangDepartment of Physiology, School of Basic Medical Sciences (L.Z., XG., Q. Wang, S.J., S.Z., N.X., Y.C., W.H., E.Y.L.), Zhejiang University School of Medicine, Hangzhou, China.
Chun TangDepartment of Nephrology, Center of Nephrology and Urology. the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China (X.W., C.T., L.F., Z.Z.).
Suhan ZhouDepartment of Physiology, School of Basic Medical Sciences (L.Z., XG., Q. Wang, S.J., S.Z., N.X., Y.C., W.H., E.Y.L.), Zhejiang University School of Medicine, Hangzhou, China.
Nan XuDepartment of Physiology, School of Basic Medical Sciences (L.Z., XG., Q. Wang, S.J., S.Z., N.X., Y.C., W.H., E.Y.L.), Zhejiang University School of Medicine, Hangzhou, China.
Yu CuiDepartment of Physiology, School of Basic Medical Sciences (L.Z., XG., Q. Wang, S.J., S.Z., N.X., Y.C., W.H., E.Y.L.), Zhejiang University School of Medicine, Hangzhou, China.
Weipeng HuDepartment of Physiology, School of Basic Medical Sciences (L.Z., XG., Q. Wang, S.J., S.Z., N.X., Y.C., W.H., E.Y.L.), Zhejiang University School of Medicine, Hangzhou, China.
Lingyan FeiDepartment of Nephrology, Center of Nephrology and Urology. the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China (X.W., C.T., L.F., Z.Z.).
Zhihua ZhengDepartment of Nephrology, Center of Nephrology and Urology. the Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China (X.W., C.T., L.F., Z.Z.).
Limeng ChenDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College (L.C.).
Marcel O SchmidtLombardi Cancer Center (M.O.S., A.W.), Georgetown University, Washington, DC.
Qichun WeiDepartment of Radiation Oncology, Second Affiliated Hospital (Q. Wei), Zhejiang University School of Medicine, Hangzhou, China.
Jingwei ZhaoDepartment of Anatomy, Histology and Embryology, Institute of Neuroscience, School of Basic Medical Sciences (J.Z.), Zhejiang University School of Medicine, Hangzhou, China.
Robert LabesInstitute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (L.Z., R.L., A.P., E.Y.L.).
Andreas PatzakInstitute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (L.Z., R.L., A.P., E.Y.L.).
Christopher S WilcoxDivision of Nephrology and Hypertension (L.L., C.S.W., E.Y.L.), Georgetown University, Washington, DC.
Xiaodong FuDepartment of Gynecology and Obstetrics, the Sixth Affiliated Hospital (X.F.), Guangzhou Medical University, China.
Anton WellsteinLombardi Cancer Center (M.O.S., A.W.), Georgetown University, Washington, DC.
En Yin LaiFrom the Department of Physiology, School of Basic Medical Sciences (L.Z., E.Y.L.), Guangzhou Medical University, China.
Zhejiang University · CNGeorgetown University · USSun Yat-sen University · CNHumboldt-Universität zu Berlin · DEGuangzhou Medical University · CNPeking Union Medical College Hospital · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

Renal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8M
BIOLOGY AND PATHOLOGY OF A MODULATOR OF FGFR01CA071508 · NCI · GEORGETOWN UNIVERSITY · PI WELLSTEIN, ANTON · 1997 to 2010
$2.9M
NCI NIH HHS R01 CA071508NHLBI NIH HHS P01 HL068686
6 · The paper itself

Abstract

Acute kidney injury (AKI) causes multiple organ dysfunction. Here, we identify a possible mechanism that can drive brain vessel injury after AKI. We induced 30-minute bilateral renal ischemia-reperfusion injury in C57Bl/6 mice and isolated brain microvessels and macrovessels 24 hours or 1 week later to test their responses to vasoconstrictors and found that after AKI brain vessels were sensitized to Ang II (angiotensin II). Upregulation of FGF2 (fibroblast growth factor 2) and FGFBP1 (FGF binding protein 1) expression in both serum and kidney tissue after AKI suggested a potential contribution to the vascular sensitization. Administration of FGF2 and FGFBP1 proteins to isolated healthy brain vessels mimicked the sensitization to Ang II after AKI. Brain vessels in

Indexed as

Acute Kidney InjuryAngiotensin IIAnimalsBrainIntercellular Signaling Peptides and ProteinsMesenteric ArteriesMice, Inbred C57BLMice, KnockoutPhenylurea CompoundsPyrimidinesReceptor, Fibroblast Growth Factor, Type 1Reperfusion InjuryVasoconstrictor AgentsAngiotensin IIFgfbp1 protein, mouseinfigratinibIntercellular Signaling Peptides and ProteinsPhenylurea CompoundsPyrimidinesReceptor, Fibroblast Growth Factor, Type 1Vasoconstrictor Agentsacute kidney injuryangiotensinbrainfibroblast growth factor 2mice

Identifiers

PMID33040621
PMCPMC9112323
OpenAlexW3091873053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.