Trial reportClinical rehabilitation2021
Can the early use of botulinum toxin in post stroke spasticity reduce contracture development? A randomised controlled trial.
Trial report in Clinical rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01882556 (Is it Clinically Effective to Treat Arm Flexor Spasticity, With Botulinum Toxin - Type A), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is it Clinically Effective to Treat Arm Flexor Spasticity, With Botulinum Toxin - Type A (BoNTA) and Physiotherapy, as Soon as Signs of Abnormal Muscle Activity Are Observed?
Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Trial
- Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial.Clinical rehabilitation · 2023Trial
- Construction and verification of a nomogram model for predicting the risk of post-stroke spasticity: a retrospective study.Annals of medicine · 2026Article
- Should Paratonia Be Considered a Movement Disorder? Implications for Clinical Management.Movement disorders clinical practice · 2026Article
- Early Treatment of Post-Stroke Spasticity with Botulinum Toxin Type A: Myth or Reality?Toxins · 2026Review
- Efficacy of radial shock wave therapy for ankle spasticity in patients with stroke within 3 months of onset: a prospective quasi-experimental study.Journal of neuroengineering and rehabilitation · 2026Article
- Review
- Radial Extracorporeal Shock Wave Therapy for Lower-Limb Spasticity in an Individual With Subacute Stroke: A Case Report.Clinical case reports · 2026Article
- Targeted and Sequential Cryoneurolysis Improves Gait After Botulinum-Toxin Unresponsiveness in Post-Stroke Spasticity: A Laboratory-Verified Case.Neurology international · 2026Article
- Patient-Centred and Daily Life-Oriented Botulinum Toxin Treatment for Stroke Survivors with Upper Extremity Spasticity-Effects and Practical Aspects.Journal of clinical medicine · 2025Article
- Article
- Botulinum Toxin Treatment in Hereditary Spastic Paraplegia-A Comprehensive Review and Update.Toxins · 2025Review
- The effect of short-term treatment with botulinum toxin a on muscle stiffness in stroke patients: an exploratory study.Journal of rehabilitation medicine · 2025Article
- Optimizing Recovery: An Opportunity to Improve Access to Post-stroke Rehabilitation Care in Rural Settings.Cureus · 2025Article
- Combined Extracorporeal Shock Wave Therapy and Botulinum Toxin Injection for Spasticity in the Acute Phase of Spinal Cord Injury: A Case Report.Progress in rehabilitation medicine · 2025Article
- Long-Term Management of Post-Stroke Spasticity with Botulinum Toxin: A Retrospective Study.Toxins · 2024Article
- Surgical reconstruction for spasticity and contracture: An underutilised rehabilitative strategy of adult stroke.JRSM open · 2024Review
- Article
- Botulinum neurotoxin as early treatment in acute-onset lesional hemiballism.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis.Toxins · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveDoes early treatment of spasticity with botulinum-toxin (BoNTA), in (hyper)acute stroke patients without arm-function, reduce contractures and improve function.
designRandomised placebo-controlled-trial.
settingSpecialised stroke-unit. PARTICIPANTS &
interventionPatients with an Action Research Arm Test (ARAT) grasp-score⩽2 who developed spasticity within six-weeks of a first stroke were randomised to receive injections of: 0.9%sodium-chloride solution (placebo) or onabotulinumtoxin-A (treatment). OUTCOME-MEASURES: Spasticity, contractures, splint use and arm function (ARAT) were taken at baseline, 12-weeks post-injection and six-months after stroke. Additionally, spasticity and contractures were measured at weeks-two, four and six post-injection.
resultsNinety three patients were randomised. Mean time to intervention was 18-days (standard deviation = 9.3). Spasticity was lower in the treatment group with difference being significant between week-2 to 12 (elbow) and week-2 to 6 (wrist). Mean-difference (MD) varied between -8.5(95% CI -17 to 0) to -9.4(95% CI -14 to -5) µV.Contracture formation was slower in the treatment group. Passive range of motion was higher in the treatment group and was significant at week-12 (elbow MD6.6 (95% CI -0.7 to -12.6)) and week-6 (wrist MD11.8 (95% CI 3.8 to 19.8)). The use of splints was lower in the treatment group odds ratio was 7.2 (95% CI 1.5 to 34.1) and 4.2 (95% CI 1.3 to 14.0) at week-12 and month-6 respectively.Arm-function was not significantly different between the groups MD2.4 (95% CI -5.3 to 10.1) and 2.9 (95% CI -5.8 to 11.6) at week-12 and month-6 respectively.
conclusionBoNTA reduced spasticity and contractures after stroke and effects lasted for approximately 12-weeks. BoNTA reduced the need for concomitant contracture treatment and did not interfere with recovery of arm function.
trial registrationEudraCT (2010-021257-39) and ClinicalTrials.gov-Identifier: NCT01882556.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.