Observational studyBJOG : an international journal of obstetrics and gynaecology2021
Chikungunya infection in pregnancy - reassuring maternal and perinatal outcomes: a retrospective observational study.
Observational study in BJOG : an international journal of obstetrics and gynaecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- A randomized, double-blinded Phase 3 study to demonstrate lot-to-lot consistency and to confirm immunogenicity and safety of the live-attenuated chikungunya virus vaccine candidate VLA1553 in healthy adults†.Journal of travel medicine · 2024Trial
- Neurological and neurodevelopmental outcomes in neonates and children after maternal chikungunya infection in pregnancy: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- In-utero exposure to chikungunya and child morbimortality: a population-based study using linked routine data.Nature communications · 2026Article
- Viral threats to pregnancy: Global health risks in the era of pandemics.Advances in virus research · 2026Review
- Preexisting yellow fever virus and West Nile virus immunity and pregnancy outcomes in a Nigerian cohort with endemic orthoflavivirus exposure.Emerging microbes & infections · 2025Article
- Maternal-Fetal Implications of Chikungunya Virus Infection: An Updated Review.Diagnostics (Basel, Switzerland) · 2025Review
- Chikungunya virus and other emerging arthritogenic alphaviruses.Nature reviews. Microbiology · 2025Review
- Mothers and mosquitoes: climate change contributes to the spread of vector-borne pathogens posing a substantial threat to pregnant women.Seminars in immunopathology · 2025Review
- Neurodevelopmental Follow-Up in Children with Intrauterine and Perinatal Exposure to Chikungunya Virus.The Journal of pediatrics · 2025Article
- Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Neonatal outcomes associated with maternal arbovirus infection (dengue, Zika, and chikungunya) among pregnant women with obstetric complications in Brazil: a cross-sectional study.Revista da Sociedade Brasileira de Medicina Tropical · 2025Article
- Arboviruses and pregnancy: are the threats visible or hidden?Tropical diseases, travel medicine and vaccines · 2024Article
- Serological and Molecular Epidemiology of Chikungunya Virus Infection in Vietnam, 2017-2019.Viruses · 2023Article
- The Innate Immune Response in DENV- and CHIKV-Infected Placentas and the Consequences for the Fetuses: A Minireview.Viruses · 2023Review
- Factors Associated with Chikungunya Infection among Pregnant Women in Grenada, West Indies.The American journal of tropical medicine and hygiene · 2023Article
- Chikungunya fever.Nature reviews. Disease primers · 2023Review
- Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana.Viruses · 2022Article
- A Retrospective Study of the Seroprevalence of Dengue Virus and Chikungunya Virus Exposures in Nigeria, 2010-2018.Pathogens (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV).
designRetrospective observational study.
settingGrenada. POPULATION: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible.
methodsThis descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA.
main outcome measuresPrimary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity.
resultsOf 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%).
conclusionCHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV. TWEETABLE ABSTRACT: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.
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