ArticlePsychophysiology2021
Impaired vasodilation in pregnant African Americans: Preliminary evidence of potential antecedents and consequences.
Article in Psychophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The physiological cost of coping: a systematic review and meta-analysis on discrimination and heart rate variability.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2026Pooled it
- Self-reported experiences of interpersonal racial discrimination and maternal and neonatal health: a systematic review and meta-analysis.Frontiers in reproductive health · 2026Review
- Ecological Impacts of Structural Racism on Health Disparity Through Its Determinants and Mediating Factors: A Case Study on Low Birthweight in Three Race/Ethnicity Groups in the United States.International journal of environmental research and public health · 2025Article
- African Americans with a family history of cardiovascular disease show lower endothelial-dependent vasodilation.Physiological reports · 2025Article
- Pathways to maternal health inequities: Structural racism, sleep, and physiological stress.Brain, behavior, and immunity · 2025Review
- Turning stress into success: A festschrift in honor of Janice Kiecolt-Glaser.Comprehensive psychoneuroendocrinology · 2024Article
- The Association of Racism and Discrimination in Disparities of Hypertensive Disorders of Pregnancy in the United States: An Analysis of PRAMS Data.Maternal and child health journal · 2024Article
- Heart Rate Variability and Pregnancy Complications: Systematic Review.Interactive journal of medical research · 2023Review
- Lifetime stressor exposure, systemic inflammation during pregnancy, and preterm birth among Black American women.Brain, behavior, and immunity · 2022Article
- Higher cardiac vagal activity predicts lower peripheral resistance 6 years later in European but not African Americans.American journal of physiology. Heart and circulatory physiology · 2021Article
- The Cardiovascular Conundrum in Ethnic and Sexual Minorities: A Potential Biomarker of Constant Coping With Discrimination.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Significant health disparities exist between African Americans (AA) and European Americans (EA) in hypertension and hypertension-related disorders. Evidence suggests that this is due to impaired vasodilation in AAs. Pregnancy is a potent systemic vasodilatory state. However, differences in vasodilation between AAs and EAs have not been investigated in pregnancy. We sought to examine the effects of pregnancy on vasodilation in AA and EA women and how this might be related to discrimination and low birth weight in their offspring. Hemodynamics [blood pressure (MAP), cardiac output (CO), total peripheral resistance (TPR)] and heart rate variability (HF-HRV) were examined at baseline in 40 pregnant AAs (n = 20) and EAs (n = 20) and matched nonpregnant women (n = 40). The Experiences of Discrimination scale and birth weight were also measured in the offspring of the pregnant participants. Whereas pregnancy was associated with decreased MAP independent of race, AAs showed impaired vasodilation independent of pregnancy status as indicated by greater TPR despite greater HF-HRV. In AAs, but not EAs, reports of fewer incidences of discrimination were associated with greater TPR. Finally, the HF-HRV of EA mothers was inversely related to the birth weight of their offspring but was uncorrelated in AAs. We report novel evidence of impaired vasodilation to an endogenous vasodilatory stimulus in AAs. Higher TPR was related to discrimination in AAs and higher HF-HRV was related to low birth weight in EAs. These findings have implications for understanding the intergenerational transmission of impaired vasodilation in AAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.