Evidence map›Paper›PMID 33040317›Full record

ArticleCurrent topics in behavioral neurosciences2021

Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder.

Diego Librenza-Garcia, Jee Su Suh, Devon Patrick Watts, Pedro Lemos Ballester, Luciano Minuzzi, Flavio Kapczinski, Benicio N Frey

Abstract read
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In one paragraph

Article in Current topics in behavioral neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Differentiating Between Major Depressive Disorder and Bipolar Disorder.Advances in experimental medicine and biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diego Librenza-GarciaMood Disorders Program, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Jee Su SuhNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Devon Patrick WattsNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Pedro Lemos BallesterNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Luciano MinuzziNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Flavio KapczinskiMood Disorders Program, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Benicio N FreyNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada. freybn@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroprogression is associated with structural and functional brain changes that occur in parallel with cognitive and functioning impairments. There is substantial evidence showing early white matter changes, as well as trajectory-related gray matter alterations. Several structures, including prefrontal, parietal, temporal cortex, and limbic structures, seem to be altered over the course of bipolar disorder, especially associated with the number of episodes and length of the disease. An important limitation is that most of the studies used either a cross-sectional design or a short follow-up period, which may be insufficient to identify all neuroprogressive changes over time. In addition, the heterogeneity of patients with bipolar disorder is another challenge to determine which subjects will have a more pernicious trajectory. Larger studies and the use of new techniques, such as machine learning, may help to enable more discoveries and evidence on the role of neuroprogression in BD.

Indexed as

Bipolar DisorderBrainCerebral CortexCross-Sectional StudiesHumansMagnetic Resonance ImagingPrefrontal CortexBipolar disorderFunctional MRINeuroprogressionStructural MRI

Identifiers

PMID33040317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.