Evidence map›Paper›PMID 33040204›Full record

ArticleSurgery today2021

Optimal timing of surgery in infants with prenatally diagnosed isolated left-sided congenital diaphragmatic hernia: a multicenter, cohort study in Japan.

Masaya Yamoto, Satoko Ohfuji, Naoto Urushihara, Keita Terui, Kouji Nagata, Tomoaki Taguchi, Masahiro Hayakawa, Shoichiro Amari, Kouji Masumoto, Tadaharu Okazaki and 12 more

Abstract read
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In one paragraph

Article in Surgery today, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Masaya YamotoDepartment of Pediatric Surgery, Shizuoka Children's Hospital, 860 Urushiyama, Aoi-ku, Shizuoka, 420-8660, Japan. ped.surg1018@gmail.com.ORCID http://orcid.org/0000-0001-6660-362X
Satoko OhfujiDepartment of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan.
Naoto UrushiharaDepartment of Pediatric Surgery, Shizuoka Children's Hospital, 860 Urushiyama, Aoi-ku, Shizuoka, 420-8660, Japan.
Keita TeruiDepartment of Pediatric Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kouji NagataDepartment of Pediatric Surgery, Faculty of Medicine Graduate School of Medical Sciences School of Medicine, Kyushu University, Fukuoka, Japan.
Tomoaki TaguchiDepartment of Pediatric Surgery, Faculty of Medicine Graduate School of Medical Sciences School of Medicine, Kyushu University, Fukuoka, Japan.
Masahiro HayakawaCenter for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.
Shoichiro AmariDepartment of Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Kouji MasumotoDepartment of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Tadaharu OkazakiDepartment of Pediatric Surgery, Juntendo University Urayasu Hospital, Chiba, Japan.
Noboru InamuraDepartment of Pediatrics, Faculty of Medicine Hospital, Kindai University, Osaka-Sayama, Japan.
Katsuaki ToyoshimaDepartments of Neonatology, Kanagawa Childrens Medical Center, Yokohama, Japan.
Keiichi UchidaSecond Department of Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Taizo FurukawaDepartment of Pediatric Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Manabu OkawadaDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Akiko YokoiDepartment of Pediatric Surgery, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Yukata KanamoriDivision of Surgery, National Center for Child Health and Development, Tokyo, Japan.
Noriaki UsuiDepartment of Pediatric Surgery, Osaka Women's and Children's Hospital, Izumi, Japan.
Yuko TazukeDepartment of Pediatric Surgery, Osaka University School of Medicine Graduate School of Medicine, Osaka, Japan.
Ryuta SakaDepartment of Pediatric Surgery, Osaka University School of Medicine Graduate School of Medicine, Osaka, Japan.
Hiroomi OkuyamaDepartment of Pediatric Surgery, Osaka University School of Medicine Graduate School of Medicine, Osaka, Japan.
Japanese Congenital Diaphragmatic Hernia Study Group

Funding

Japanese Agency for Medical Research and Development (AMED) JP17ek0109264h0001Japanese Agency for Medical Research and Development (AMED) JP18ek0109264h0002Japanese Agency for Medical Research and Development (AMED) JP19ek0109264h0003
6 · The paper itself

Abstract

purposeTo date, there is no compelling evidence of the optimal timing of surgery for congenital diaphragmatic hernia (CDH). This study aimed to establish the optimal timing of surgery in neonates with isolated left-sided CDH.

methodsThis multicenter cohort study enrolled 276 patients with isolated left-sided CDH at 15 institutions. Based on the timing of surgery, the patients were classified into four groups [< 24 h (G1), 24-47 h (G2), 48-71 h (G3), and ≥ 72 h (G4)]. The clinical outcomes were compared among the groups using a logistic regression model, after adjusting for potential confounders, such as disease severity.

resultsMultivariate analyses showed that G2 also had a lower mortality rate than the other groups. In mild and severe cases, there were no significant differences in mortality across the four groups. In moderate cases, G2 resulted in significantly increased survival rates, compared with G1.

conclusionThe study results suggest that surgery within 24 h of birth is not recommended for patients with moderate severity CDH, that there is no benefit in the delay of surgery for more than 72 h in mild severity CDH patients, and that there is no definite optimal time to perform surgery in severe cases of CDH.

Indexed as

Prenatal DiagnosisCohort StudiesFemaleHernias, Diaphragmatic, CongenitalHumansInfant, NewbornJapanLogistic ModelsMaleMulticenter Studies as TopicSeverity of Illness IndexSurvival RateTime FactorsTreatment OutcomeCohort studyCongenital diaphragmatic herniaGentle ventilationMulticenterTiming of surgery

Identifiers

PMID33040204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.