Evidence map›Paper›PMID 33040199›Full record

SynthesisNeuropsychology review2021

Evaluation of Discriminative Detection Abilities of Social Cognition Measures for the Diagnosis of the Behavioral Variant of Frontotemporal Dementia: a Systematic Review.

Alessandra Dodich, Chiara Crespi, Gaia C Santi, Stefano F Cappa, Chiara Cerami

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuropsychology review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Social cognition in mild cognitive impairment and dementia: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
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  6. Review
  7. Perception of facial trustworthiness in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2026
    Article
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  11. Article
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  13. Review
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  17. Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities-focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  18. Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023
    Review
  19. The FACE test: a new neuropsychological task to assess the recognition of complex mental states from faces.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alessandra DodichCeRiN, Centre for Mind/Brain Sciences-CIMeC, University of Trento, Rovereto, Italy.
Chiara CrespiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Gaia C SantiScuola Universitaria Superiore IUSS Pavia, Pavia, Italy.
Stefano F CappaScuola Universitaria Superiore IUSS Pavia, Pavia, Italy.
Chiara CeramiCognitive Computational Neuroscience Research Unit, IRCCS Mondino Foundation, Pavia, Italy. chiara.cerami@iusspavia.it.ORCID 0000-0003-1974-3421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of social tasks in the neuropsychological assessment of the behavioral variant of frontotemporal dementia (bvFTD) is at present not required by diagnostic guidelines, despite extensive literature shows relevant social cognitive dysfunctions in such patients. In this systematic review, we explored the clinical maturity of social cognition measures in the diagnosis of bvFTD. Papers were selected according to the PRISMA guidelines by searching the PubMed and Medline databases. Only papers reporting indices of diagnostic accuracy and/or sensitivity/specificity in classifying bvFTD from controls or from other relevant diseases were considered. Quality of evidence was assessed through QUADAS-2. Among the 663 articles entered in the paper selection only 14 papers were eligible for the scope of the present review and showed an overall moderate-to-low quality. The major risk of bias was the lack of pathological confirmation. The evaluation of the accuracy of social cognition tasks in bvFTD detection compared to normal controls, as well as in the discrimination with Alzheimer's disease and psychiatric patients, is mainly focused on emotion recognition and theory of mind. However, the use of different cognitive measures, variable task formats and the limited normative data hamper study comparability. Although literature seems to suggest that emotion recognition and ToM tasks could be the best choice to ensure a high diagnostic accuracy in clinical settings, further comparative studies are required and no recommendation concerning the use of a specific social task in bvFTD diagnosis can be currently provided.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaCognitionDiagnosis, DifferentialHumansNeuropsychological TestsSocial CognitionAccuracy of socio-emotional markers in the bvFTDBehavioral variant of Frontotemporal dementiaCognitive assessment in dementiaCognitive marker of bvFTDSocial cognition disorders

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.