ArticleEuropean addiction research2021
Cannabis Use during Pregnancy and Risk of Adverse Birth Outcomes: A Longitudinal Cohort Study.
Article in European addiction research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cannabis Use in Pregnancy and Neonatal Outcomes: A Systematic Review and Meta-Analysis.Cannabis and cannabinoid research · 2024Pooled it
- Birth, cognitive and behavioral effects of intrauterine cannabis exposure in infants and children: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2024Pooled it
- The Effects of Cannabis on Female Reproductive Health Across the Life Course.Cannabis and cannabinoid research · 2021Pooled it
- Recreational Cannabis Use During Human Pregnancy: Its Effects on the Placenta and Endocannabinoid System.International journal of molecular sciences · 2026Review
- Beliefs and perceived benefits and harms of perinatal cannabis use among pre- and post-pregnancy women.Drug and alcohol dependence reports · 2025Article
- Meta-analysis of maternal and neonatal outcomes of cannabis use in pregnancy current to March 2024.Maternal health, neonatology and perinatology · 2025Review
- Prenatal Cannabis Use and Neonatal Outcomes: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2025Article
- Cannabis use and cannabis use disorders and their treatment in the Europe.European archives of psychiatry and clinical neuroscience · 2025Review
- Alcohol, Tobacco and Illicit Drug Use During Pregnancy in the Longitudinal BELpREG Cohort in Belgium Between 2022 and 2024.Journal of clinical medicine · 2025Article
- Impact of prenatal exposure to delta 9-tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories.Pediatric obesity · 2025Article
- Cannabis use patterns, motivations, and reasons for abstinence in pregnancy.Frontiers in psychiatry · 2025Article
- Beyond Infections: Exploring Immune-Mediated Pathways Linking Cannabis and Emerging Environmental Contaminants to Neurodevelopmental Outcomes.Advances in experimental medicine and biology · 2025Review
- Substance and alcohol use in pregnant women attending antenatal care at a tertiary hospital in Johannesburg, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- Evolution of the substance use landscape: Implications for contingency management.Journal of applied behavior analysis · 2025Review
- Reduced fetal cerebral blood flow predicts perinatal mortality in a mouse model of prenatal alcohol and cannabinoid exposure.BMC pregnancy and childbirth · 2024Article
- Prenatal Exposure to Cannabis: Effects on Childhood Obesity and Cardiometabolic Health.Current obesity reports · 2024Review
- Improving the quality of antenatal screening and early intervention for alcohol and other drug use: protocol for a multi-stage approach to systems reform.Addiction science & clinical practice · 2024Article
- Cannabis use, cannabis use disorder and mental health disorders among pregnant and postpartum women in the US: A nationally representative study.Drug and alcohol dependence · 2023Article
- Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy.International journal of molecular sciences · 2023Review
- Prenatal cannabinoid exposure: why expecting individuals should take a pregnancy pause from using cannabinoid products.Frontiers in pediatrics · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith recent changes in legislation regulating recreational and medical cannabis use around the globe, increased use in pregnancy is to be expected.
objectivesTo investigate the association between cannabis use during pregnancy and birth outcomes.
methodData from the Norwegian Mother and Child Cohort Study (MoBa), a prospective pregnancy cohort, were used. Participants were recruited from all over Norway between 1999 and 2008: 9,312 women with 10,373 pregnancies who reported use of cannabis before or in pregnancy. Women reported on their illegal drug use before pregnancy and at pregnancy weeks 17/18 and 30 and at 6 months postpartum. Linear regression was used to estimate crude and adjusted effects of prenatal cannabis exposure on birth outcomes.
resultsIn 10,101 pregnancies, women had used cannabis before pregnancy but not during pregnancy. In 272 pregnancies, women had used cannabis during pregnancy, and among these, in 63 pregnancies, women had used cannabis in at least 2 periods. In adjusted analyses for potential confounders, only cannabis use during at least 2 periods of pregnancy showed statistically significant effects on birth weight. The effect was observed in the complete cohort (B = -228 g, 95% CI = -354 to -102, p < 0.001) and for the subgroup where information about the child's father was available (B = -225 g, 95% CI = -387 to -63, p = 0.01). Our results may indicate that prolonged use causes more harm, whereas short-term use did not indicate adverse effects on birth outcomes.
conclusionsThere was a statistically significant and clinically relevant association between the use of cannabis during pregnancy and reduced birth weight. Clinicians should screen not only for cannabis use but also for the length and intensity of use as part of a comprehensive substance use screening.
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