Evidence map›Paper›PMID 33040024›Full record

ArticleThe Journal of biological chemistry2020

Iron-mediated degradation of ribosomes under oxidative stress is attenuated by manganese.

Daniel G J Smethurst, Nikolay Kovalev, Erica R McKenzie, Dimitri G Pestov, Natalia Shcherbik

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Ribosome Molecular Aging Shapes Translation Dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  3. The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Trace Elements in Medicinal Metallomics.Mini reviews in medicinal chemistry · 2025
    Review
  6. Ribosome Assembly and Repair.Annual review of cell and developmental biology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Daniel G J SmethurstDepartment of Cell Biology and Neuroscience, Rowan University, School of Osteopathic Medicine, Stratford, New Jersey, USA.
Nikolay KovalevDepartment of Cell Biology and Neuroscience, Rowan University, School of Osteopathic Medicine, Stratford, New Jersey, USA.
Erica R McKenzieCivil and Environmental Engineering Department, Temple University, Philadelphia, Pennsylvania, USA.
Dimitri G PestovDepartment of Cell Biology and Neuroscience, Rowan University, School of Osteopathic Medicine, Stratford, New Jersey, USA.
Natalia ShcherbikDepartment of Cell Biology and Neuroscience, Rowan University, School of Osteopathic Medicine, Stratford, New Jersey, USA. Electronic address: shcherna@rowan.edu.
Rowan University · USTemple University · US

Funding

Translational Rescue Mechanisms in EukaryotesR01GM114308 · NIGMS · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · PI SHCHERBIK, NATALIA · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM114308
6 · The paper itself

Abstract

Protein biosynthesis is fundamental to cellular life and requires the efficient functioning of the translational machinery. At the center of this machinery is the ribosome, a ribonucleoprotein complex that depends heavily on Mg

Indexed as

Oxidative StressIronManganeseRibosomesRNA, FungalRNA, RibosomalSaccharomyces cerevisiaeIronManganeseRNA, FungalRNA, Ribosomalcell viabilitydegradation of ribosomesironiron metabolismmanganesemetalsoxidantsoxidative stressribosomal ribonucleic acid (rRNA)ribosomeribosome structureRNA foldingyeast

Identifiers

PMID33040024
PMCPMC7863898
OpenAlexW3092221472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.