ArticleDiabetes & metabolic syndrome
Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients.
Article in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- ACE2 Expression and Clinical Biomarkers in COVID-19: Associations With Disease Severity.Pulmonary medicine · 2026Article
- Elevated IL-6 and IL-10 Levels as Prognostic Biomarkers in COVID-19 Pneumonia: A Comparative Study in Mexican Patients.Healthcare (Basel, Switzerland) · 2025Article
- Association between COVID-19 severity with liver abnormalities: A retrospective study in a referral hospital in Indonesia.Narra J · 2024Article
- Observational
- Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series.Brain, behavior, & immunity - health · 2024Article
- Current Views About the Link between SARS-CoV-2 and the Liver: Friends or Foe?Endocrine, metabolic & immune disorders drug targets · 2024Article
- Clinico-epidemiological profile of non-survivors of COVID-19 during the last two waves in a tertiary care hospital of North India: A retrospective descriptive study.Journal of family medicine and primary care · 2023Article
- COVID-19 and Fatty Liver Disorders.Journal of clinical medicine · 2023Review
- Liver Damage and COVID-19: At Least a "Two-Hit" Story in Systematic Review.Current issues in molecular biology · 2023Review
- Implications of metabolic dysfunction associated fatty liver disease in COVID-19.World journal of clinical cases · 2023Review
- Liver Function Abnormalities in COVID-19 Patients and their Association with Age and Sex: a Cross-Sectional Study.Archives of Razi Institute · 2023Article
- Clinical and laboratory profile and outcomes of hospitalized COVID-19 patients with type 2 diabetes mellitus in Ghana - A single-center study.Endocrinology, diabetes & metabolism · 2023Article
- Intestinal Alkaline Phosphatase Activity and Efficiency Are Altered in Severe COVID-19 Patients.Gastro hep advances · 2023Article
- Living with liver disease in the era of COVID-19-the impact of the epidemic and the threat to high-risk populations.World journal of clinical cases · 2022Review
- Biosensors based detection of novel biomarkers associated with COVID-19: Current progress and future promise.Biosensors & bioelectronics: X · 2022Review
- COVID-19 associated liver injury: A general review with special consideration of pregnancy and obstetric outcomes.World journal of gastroenterology · 2022Review
- Utility of Biochemical Markers in Predicting Severe COVID-19: Experience from a Tertiary Hospital in South India.EJIFCC · 2022Article
- Liver function tests in COVID 19: A retrospective record-based study from a tertiary care centre in urban Maharashtra, India.Medical journal, Armed Forces India · 2022Article
- Influence of laboratory biomarkers on inflammatory indices for assessing severity progression in COVID-19 cases.Journal of family medicine and primary care · 2022Article
- Secondary Sclerosing Cholangitis in a Critically Ill Patient with Severe SARS-CoV-2 Infection: A Possibly Emergent Entity during the Current Global Pandemic.GE Portuguese journal of gastroenterology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background- COVID-19 caused by SARS-CoV-2 leads to myriad range of organ involvement including liver dysfunction.
aimTo analyse the liver function in patients with COVID-19 and their association with respect to age, sex, severity of disease and clinical features. MATERIALS AND
methodsThis study was a cross-sectional study done at Rajendra Institute of Medical Sciences, Ranchi. 91 patients admitted with confirmed SARS-CoV-2 infection were included in this study and divided into asymptomatic, mild, moderate and severe groups. Liver function tests were compared among different severity groups.
resultsOf 91 patients with COVID-19, 70 (76.9%) had abnormal liver function. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin levels was 1-2 × ULN in 33(36.3%), 34(37.3%), 12(13.2%), 6(6.6%) cases and >2 × ULN in 20(22%), 18(19.8%), 7(7.7%) and 2 (2.2%) cases respectively. Mean AST and ALP levels among different severity groups of COVID-19 was statistically significant (p < 0.05) whereas mean ALT and total bilirubin levels was statistically non-significant (p > 0.05). There was no statistical difference between males and females with regard to abnormal liver function. Liver injury was seen in 64.3% cases of hypertension and 73.3% cases of diabetes. Fever, myalgia, headache and breathlessness were found to be correlated significantly with severity of disease.
conclusionLiver injury is common in SARS-CoV-2 infection and is more prevalent in the severe disease group. Aspartate transaminase and alkaline phosphatase are better indicators of covid-19 induced liver injury than alanine transaminase and total bilirubin.
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