ArticleNeurobiology of aging2020
Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer's disease.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Within-Individual BOLD Signal Variability and its Implications for Task-Based Cognition: A Systematic Review.Neuropsychology review · 2024Pooled it
- Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia.Brain : a journal of neurology · 2026Article
- Subtype-specific enhancement of implicit statistical learning in migraine: insights from BOLD signal variability.The journal of headache and pain · 2026Article
- Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia.Neurology · 2025Article
- Modulation of brain signal variability in visual cortex reflects aging, GABA, and behavior.eLife · 2025Article
- Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease.Brain : a journal of neurology · 2024Review
- Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.Brain : a journal of neurology · 2023Article
- Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy aging subjects.Human brain mapping · 2022Article
- Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study.NeuroImage. Clinical · 2022Observational
- Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology.Developmental cognitive neuroscience · 2021Article
- Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer's Disease.Brain sciences · 2021Article
- The human connectome in Alzheimer disease - relationship to biomarkers and genetics.Nature reviews. Neurology · 2021Review
- Altered basal forebrain BOLD signal variability at rest in posttraumatic stress disorder: A potential candidate vulnerability mechanism for neurodegeneration in PTSD.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Recent functional magnetic resonance imaging studies have demonstrated that moment-to-moment variability in the blood oxygen level-dependent (BOLD) signal is related to age differences, cognition, and symptomatic Alzheimer's disease (AD). However, no studies have examined BOLD variability in the context of preclinical AD. We tested relationships between resting-state BOLD variability and biomarkers of amyloidosis, tauopathy, and neurodegeneration in a large (N = 321), well-characterized sample of cognitively normal adults (age = 39-93), using multivariate machine learning techniques. Furthermore, we controlled for cardiovascular health factors, which may contaminate resting-state BOLD variability estimates. BOLD variability, particularly in the default mode network, was related to cerebrospinal fluid (CSF) amyloid-β42 but was not related to CSF phosphorylated tau-181. Furthermore, BOLD variability estimates were also related to markers of neurodegeneration, including CSF neurofilament light protein, hippocampal volume, and a cortical thickness composite. Notably, relationships with hippocampal volume and cortical thickness survived correction for cardiovascular health and also contributed to age-related differences in BOLD variability. Thus, BOLD variability may be sensitive to preclinical pathology, including amyloidosis and neurodegeneration in AD-sensitive areas.
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