ReviewEBioMedicine2020
Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities.
Review in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07167173 (Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis), which is not on this map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Trends and Disparities in Post-acute Care Utilization After Hospitalization for Sepsis in the United States: A Systematic Review.Medical care · 2026Pooled it
- The core role of central nervous system in sepsis-related organ damage.Frontiers in immunology · 2025Pooled it
- Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Cognitive Health and Quality of Life After Surviving Sepsis: A Narrative Review.Journal of intensive care medicine · 2026Review
- Strategies to address implementation barriers in sepsis survivors' care transitions to home health and outpatient care: a multi-site, type 1 hybrid implementation study.BMC health services research · 2026Article
- Factors associated with mortality in older sepsis patients: a nationwide retrospective cohort study in Germany.Age and ageing · 2026Observational
- Renal dysfunction as a marker of adverse outcomes in early sepsis in the emergency department.Clinical and experimental emergency medicine · 2026Article
- Myeloid-derived suppressor cells in sepsis: drivers of persistent immunosuppression and targets for precision immunotherapy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Immune Endotype-Guided Precision Immunotherapy in Sepsis: From Transcriptomics to Bedside Application.Cureus · 2026Review
- Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging.Nature communications · 2026Article
- Sepsis insult generates different vascular response phenotypes: an unsupervised time-series clustering preclinical study.Scientific reports · 2026Article
- Bench-to-Bedside Insights into the Challenges of Immunosuppression in Sepsis.Pathogens (Basel, Switzerland) · 2026Review
- Metabolic reprogramming in sepsis-associated encephalopathy: emerging mechanisms, candidate biomarkers, and future therapeutic directions.Frontiers in medicine · 2026Review
- T cell immunometabolic dysfunction in a mouse model of cecal ligation and puncture-induced sepsis.BMC immunology · 2025Article
- Transitional care after hospitalization for sepsis in Germany- results from the population-based AVENIR cohort study.Infection · 2025Article
- Trained immunity: induction of an inflammatory memory in disease.Cell research · 2025Review
- Persistent Subclinical Inflammation and Long-term Functional and Cognitive Outcomes After Dengue Shock and Septic Shock in Vietnam.Open forum infectious diseases · 2025Article
- Rethinking post-sepsis syndrome: linking cellular dysfunction to the clinical picture.Critical care (London, England) · 2025Review
- Top 10 research priorities for sepsis research determined by patients, carers and clinicians.Anaesthesia · 2025Article
- Immunodynamic Disruption in Sepsis: Mechanisms and Strategies for Personalized Immunomodulation.Biomedicines · 2025Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a major health problem worldwide. As the number of sepsis cases increases, so does the number of sepsis survivors who suffer from "post-sepsis syndrome" after hospital discharge. This syndrome involves deficits in multiple systems, including the immune, cognitive, psychiatric, cardiovascular, and renal systems. Combined, these detrimental consequences lead to rehospitalizations, poorer quality of life, and increased mortality. Understanding the pathophysiology of these issues is crucial to develop new therapeutic opportunities to improve survival rate and quality of life of sepsis survivors. Such novel strategies include modulating the immune system and addressing mitochondrial dysfunction. A sepsis follow-up clinic may be useful to identify long-term health issues associated with post-sepsis syndrome and evaluate existing and novel strategies to improve the lives of sepsis survivors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.