Evidence map›Paper›PMID 33039414›Full record

ArticleJournal of neuroscience methods2021

Autonomous cage-side system for remote training of non-human primates.

Devon J Griggs, Julien Bloch, Shivalika Chavan, Kali M Coubrough, William Conley, Kelly Morrisroe, Azadeh Yazdan-Shahmorad

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroscience methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Devon J GriggsDept. Electrical and Computer Engineering, University of Washington, Seattle, WA, United States; Washington National Primate Research Center, Seattle, WA, United States.
Julien BlochWashington National Primate Research Center, Seattle, WA, United States; Dept. of Bioengineering, University of Washington, Seattle, WA, United States.
Shivalika ChavanDept. of Bioengineering, University of Washington, Seattle, WA, United States.
Kali M CoubroughDept. of Bioengineering, University of Washington, Seattle, WA, United States.
William ConleySouth Kitsap High School, Port Orchard, WA, United States.
Kelly MorrisroeWashington National Primate Research Center, Seattle, WA, United States.
Azadeh Yazdan-ShahmoradDept. Electrical and Computer Engineering, University of Washington, Seattle, WA, United States; Washington National Primate Research Center, Seattle, WA, United States; Dept. of Bioengineering, University of Washington, Seattle, WA, United States. Electronic address: azadehy@uw.edub.
Oregon National Primate Research Center · USUniversity of Washington · USCentral Kitsap School District · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Interdisciplinary Engineering Career Development Center in Movement and Rehabilitation SciencesK12HD073945 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, REINKENSMEYER, DAVID JAY · 2012 to 2021
$7.9M
NICHD NIH HHS K12 HD073945NIH HHS P51 OD010425
6 · The paper itself

Abstract

backgroundTraining non-human primates (NHPs) for translational medical experimentation is an essential yet time consuming process. To increase training efficiency, some training systems have been designed for NHPs to use at their home cages. Several autonomous cage-side tablet-based systems have been proposed, but none of these systems allow for remote monitoring and task modification while also being wireless, low-cost, light weight, and portable. NEW

methodHere we present ACTS: an Autonomous Cage-side Training System which meets all these criteria. ACTS consists of 1) a touchscreen tablet and a speaker attached to the subject's home cage, 2) an inexpensive reward system made from a slightly modified fish feeder, and 3), a laptop operating the system wirelessly and remotely via a router.

resultsWe were able to test the system and wirelessly train two macaques in their home cages. Remote access enabled us to control ACTS from up to 90 m, through up to 3 walls, and through a floor of a building. The device is compatible with different reward pellet sizes and could run about two hours with a ∼4 mm pellet size. The animals were able to generalize the task when transferred to a traditional experimental rig. COMPARISON WITH EXISTING

methodsThe low cost and modest skill required to build and implement ACTS lowers the barrier for NHP researchers and caregivers to deploy autonomous, remotely controlled tablet-based cage-side systems.

conclusionACTS can be used for low-cost, wireless cage-side training of NHPs being prepared for translational medical experimentation.

Indexed as

MacacaPrimatesAnimalsRewardAutonomous trainingCage-side trainingNon-human primate

Identifiers

PMID33039414
PMCPMC8384435
OpenAlexW3091949993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.