Evidence map›Paper›PMID 33039230›Full record

ArticleThe American journal of emergency medicine2021

Covid-19 associated Guillain-Barre Syndrome: Contrasting tale of four patients from a tertiary care centre in India.

Satyan Nanda, Rahul Handa, Atul Prasad, Rajiv Anand, Dhruv Zutshi, Sujata K Dass, Prabhjeet Kaur Bedi, Aarti Pahuja, Pankaj Kumar Shah, Bipan Sharma

Open access · greenAbstract readCase Reports
In one paragraph

Article in The American journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 6 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 6 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
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  13. Acute neuromuscular syndromes with respiratory failure during COVID-19 pandemic: Where we stand and challenges ahead.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022
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  15. Autoimmune complications of COVID-19.Journal of medical virology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Satyan NandaDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Rahul HandaDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India. Electronic address: rahulhanda0411@gmail.com.
Atul PrasadDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Rajiv AnandDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Dhruv ZutshiDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Sujata K DassDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Prabhjeet Kaur BediDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Aarti PahujaDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Pankaj Kumar ShahDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
Bipan SharmaDepartment of Neurology, BLK Super Speciality Hospital, New Delhi, India.
BLK Super Speciality Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlobally, more than 12 million people have been infected with COVID -19 infection till date with more than 500,000 fatalities. Although, Covid-19 commonly presents with marked respiratory symptoms in the form of cough and dyspnoea, a neurotropic presentation has been described of late as well.

objectiveIn this brief communication we report four cases of Covid-19 who presented to our hospital with features suggestive of Guillain-Barre Syndrome (GBS). DISCUSSION: The mechanisms by which SARS-CoV-2 causes neurologic damage are multifaceted, including direct damage to specific receptors, cytokine-related injury, secondary hypoxia, and retrograde travel along nerve fibres. The pathogenesis of GBS secondary to Covid-19 is not well understood. It is hypothesised that viral illnesses related GBS could be due to autoantibodies or direct neurotoxic effects of viruses.

conclusionNervous system involvement in Covid-19 may have been grossly underestimated. In this era of pandemic, it is very important for the physicians to be aware of association of GBS with Covid-19, as early diagnosis and treatment of this complication could have gratifying results. To the best of our knowledge, this is the first such case series of Guillain-Barre Syndrome associated with Covid-19 to be reported from India.

Indexed as

AgedCOVID-19FemaleGuillain-Barre SyndromeHumansIndiaMaleMiddle AgedTertiary Care Centers

Identifiers

PMID33039230
PMCPMC7493759
OpenAlexW3085730469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.