ArticlePediatric research2021
Pediatric obesity-related non-alcoholic fatty liver disease: waist-to-height ratio best anthropometrical predictor.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Tri-Ponderal Mass Index as a Screening Tool for Identifying Body Fat and Cardiovascular Risk Factors in Children and Adolescents: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Central Adiposity Versus Body Mass Index in Assessment of Adiposity-Related Differences in Physical Activity Among Schoolchildren Aged 5-12 Years in High-Risk Neighborhoods.Sports (Basel, Switzerland) · 2026Article
- The effects of ketogenic diet and calorie-restricted diet on metabolic dysfunction-associated steatotic liver disease: a retrospective study.Frontiers in nutrition · 2026Article
- Metabolic-associated steatotic liver disease in children and adolescents: a scoping review and narrative synthesis of epidemiology, risk factors, and screening approaches with emerging implications for sub-Saharan Africa.Frontiers in endocrinology · 2026Article
- Genetic insights of waist-to-height ratio on the risk of steatotic and advanced liver diseases: genome-wide association study and polygenic risk score-based analyses.Human genomics · 2025Article
- Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity.Diabetes, obesity & metabolism · 2025Article
- Effectiveness of Smartphone App for the Treatment of Pediatric Obesity: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2024Article
- Evaluation of the ability of insulin resistance and lipid-related indices to predict the presence of NAFLD in obese adolescents.Lipids in health and disease · 2024Article
- An interpretable predictive deep learning platform for pediatric metabolic diseases.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- A significant and persistent rise in the global burden of adolescent NAFLD and NASH estimated by BMI.Frontiers in public health · 2024Article
- Nonalcoholic fatty liver disease in children with obesity- observations from one clinical centre in the Western Pomerania region.Frontiers in endocrinology · 2022Article
- Clinical spectrum transition and prediction model of nonalcoholic fatty liver disease in children with obesity.Frontiers in endocrinology · 2022Article
- A Mini-Review of Pediatric Anthropometrics as Predictors of Future Insulin Resistance.Frontiers in endocrinology · 2022Review
- Dietary fiber intake and non-alcoholic fatty liver disease: The mediating role of obesity.Frontiers in public health · 2022Article
- Triglyceride: A mediator of the association between waist-to-height ratio and non-alcoholic fatty liver disease: A second analysis of a population-based study.Frontiers in endocrinology · 2022Article
- Evaluation of tri-ponderal mass index in predicting metabolic associated fatty liver disease in obese children.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in pediatric obesity. Our study aims to identify a predictive anthropometrical measure for NAFLD in obese children.
methodsWe retrospectively enrolled children and adolescents with obesity. Physical, biochemical, and ultrasound assessments were available. ROC curve tests were performed to identify the best predictor of NAFLD among waist-to-height ratio (WHR), BMI z-score, and triponderal mass index (TMI, an anthropometric index recently associated with increased adiposity in children). Subsequently, a cut-off value was identified.
resultsIn total, 1900 children and adolescents (1011 with NAFLD) were included. WHR (AUC 0.62, 95% CI 0.59-0.64) was the best predictor of NAFLD compared to BMI z-score (AUC 0.58, 95% CI 0.55-0.60) and TMI (AUC 0.58, 95% CI 0.55-0.61). WHR ≥ 0.53 in boys and 0.63 in girls displayed the best sensitivity and specificity for NAFLD presence. In addition, children with high WHR showed a significantly higher risk of NAFLD (boys: OR 2.43, 95% CI 1.61-3.68, p < 0.0001; girls: OR 1.92, 95% CI 1.58-2.34, p < 0.0001) and elevated ALT (OR 5.71, 95% CI 2.09-15.56, p = 0.0007; girls: OR 2.16, 95% CI 1.70-2.74, p < 0.0001) independent of covariates.
conclusionsWHR might represent a good anthropometric tool to candidate children and adolescents to NAFLD screening. WHR cut-off differs according to sex, being lower in boys than girls. IMPACT: Waist-to-height ratio is a better predictor of non-alcoholic fatty liver disease risk compared to other anthropometric measures in obese children and adolescents. The predictive cut-off of waist-to-height ratio differs between boys and girls, being lower in boys than girls. The use of waist-to-height ratio measurement and its cut-off in clinical practice might help clinician in identifying obese children and adolescents at risk of non-alcoholic fatty liver disease.
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