ArticlePediatric research2021
The hidden consequence of intraventricular hemorrhage: persistent cerebral desaturation after IVH in preterm infants.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Occurrence and Time of Onset of Intraventricular Hemorrhage in Preterm Neonates: A Systematic Review and Meta-Analysis of Individual Patient Data.JAMA pediatrics · 2025Pooled it
- Association of Day-1 Hemoglobin Oxygen Affinity (p50) with Severe Intraventricular Hemorrhage in Preterm Infants.Indian pediatrics · 2026Article
- Impact of posthemorrhagic ventricular dilatation on cerebral oxygenation in preterm infants with intraventricular hemorrhage.Pediatric research · 2026Article
- Cerebral monitoring responses to bedside physiological challenges in comatose post-cardiac arrest patients.Journal of clinical monitoring and computing · 2026Article
- Measuring cerebral hemodynamics and oxygen metabolism indices using NIR-TRS in premature infants from birth to term-equivalent age.Scientific reports · 2025Article
- Systematic Health Guidance and Psychological Nursing Intervention: Effects on Emotions, Sleep Quality, and Self-Efficacy in Cerebral Hemorrhage Patients.Psychiatry and clinical psychopharmacology · 2025Article
- Prediction models for intraventricular hemorrhage in very preterm infants: a systematic review.Frontiers in pediatrics · 2025Review
- Hypertensive disorders of pregnancy increase neonatal cerebral regional tissue oxygen saturation in the early postnatal period: partial mediation by preterm birth.Frontiers in cell and developmental biology · 2025Article
- Ventilatory Support, Extubation, and Cerebral Perfusion Changes in Pre-Term Neonates: A Near Infrared Spectroscopy Study.Neurotrauma reports · 2024Article
- Regional cerebral oxygen saturation variability and brain injury in preterm infants.Frontiers in pediatrics · 2024Article
- Preterm Infants off Positive Pressure Respiratory Support Have a Higher Incidence of Occult Cerebral Hypoxia.The Journal of pediatrics · 2023Observational
- Early Vital Sign Differences in Very Low Birth Weight Infants with Severe Intraventricular Hemorrhage.American journal of perinatology · 2023Article
- Neuromonitoring in neonatal critical care part II: extremely premature infants and critically ill neonates.Pediatric research · 2023Review
- Cerebral near-infrared spectroscopy monitoring to predict periventricular-intraventricular haemorrhage and neurodevelopmental outcomes in preterm infants: a protocol for a systematic review and meta-analysis.BMJ paediatrics open · 2023Article
- Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study.BMJ paediatrics open · 2023Article
- Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- A phase-II clinical trial of targeted cerebral near infrared spectroscopy using standardized treatment guidelines to improve brain oxygenation in preterm infants (BOx-II): A study protocol.Contemporary clinical trials · 2022Article
- Degree of ventriculomegaly predicts school-aged functional outcomes in preterm infants with intraventricular hemorrhage.Pediatric research · 2022Article
- Cerebral saturation reflects anterior cerebral artery flow parameters by Doppler ultrasound in the extremely premature newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- A neonatal neuroNICU collaborative approach to neuromonitoring of posthemorrhagic ventricular dilation in preterm infants.Pediatric research · 2022Review
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4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies describe a short-term decrease in cerebral oxygen saturation (StO2) after intraventricular hemorrhage (IVH) in premature infants; little is known about long-term implications.
methodsInfants born <30 weeks gestational age (GA) were included. Clinical characteristics, hemoglobin measurements, the highest grade of IVH, and white matter injury (WMI) were noted. NIRS monitoring occurred daily or every other day for 4 weeks; weekly through 36 weeks GA. Recordings were error-corrected before calculation of mean StO2 and fractional tissue oxygen extraction (FTOE). Mean StO2 and FTOE were plotted by postnatal age and injury group (IVH/no IVH; WMI/no WMI). Non-linear regression by locally estimated scatterplot smoothing was used to generate the best-fit line and CI.
resultsA total of 1237 recordings from 185 infants were included; mean length = 6.5 h; mean GA = 26.3 w; mean BW = 951 g; overall/severe IVH incidence was 29/8%, WMI incidence was 16%. IVH was independently associated with an acute drop in StO2, which remained lower for 68 d. Severe IVH was associated with lower StO2 values than mild IVH. WMI was associated with early and persistent elevation of FTOE.
conclusionIVH of any grade is associated with a prolonged cerebral desaturation and WMI is associated with prolonged elevation of FTOE. This finding is exacerbated for infants with severe IVH. IMPACT: The longitudinal impact of IVH on cerebral oxygenation has not been previously studied. IVH is associated with persistent cerebral desaturation, months in length, and is independent of anemia. More severe IVH is associated with worsened cerebral hypoxia. Infants later diagnosed with white matter injury have an early and persistent elevation of cerebral oxygen extraction (cFTOE). This cerebral desaturation, below previously identified normative ranges, may provide insight into the mechanistic link between IVH and white matter injury.
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