Evidence map›Paper›PMID 33038783›Full record

ArticleAmerican journal of otolaryngology

Dysphonia and dysphagia as early manifestations of autoimmune inflammatory myopathy.

Samuel F Weinreb, Krzysztof Piersiala, Alexander T Hillel, Lee M Akst, Simon R Best

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of otolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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  7. Dysphonia in Polymyositis/Dermatomyositis in Adults.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Samuel F WeinrebDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD, USA.
Krzysztof PiersialaDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD, USA; Division of ENT Diseases, Department of Clinical Sciences, Intervention, and Technology, Karolinska Institute, Solnavägen 1, 171 77 Stockholm, Sweden.
Alexander T HillelDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD, USA.
Lee M AkstDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD, USA.
Simon R BestDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, 601 N Caroline Street, Baltimore, MD, USA. Electronic address: sbest2@jhmi.edu.
Johns Hopkins University · USKarolinska Institutet · SE

Funding

NRSA Training CoreTL1TR003100 · NCATS · JOHNS HOPKINS UNIVERSITY · PI SAHA, SOMNATH · 2019 to 2023
$4.5M
Therapeutic DNA vaccine for Recurrent Respiratory PapillomatosisK23DC014758 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI BEST, SIMON R · 2016 to 2021
$1.0M
NCATS NIH HHS TL1 TR003100NIDCD NIH HHS K23 DC014758NIDCD NIH HHS L40 DC013350
6 · The paper itself

Abstract

purposeWhile dysphagia is a recognized manifestation of autoimmune inflammatory myopathy, a relationship between myositis and dysphonia or laryngeal pathology is not well-documented. We therefore sought to describe the spectrum of laryngeal disorders present in myositis patients, evaluate whether any specific conditions are overrepresented among these patients compared to a large treatment-seeking population, and examine the clinical course and outcomes of these symptoms. MATERIALS AND

methodsThis was a retrospective chart review, including all patients seen at the Johns Hopkins Voice Center between January 2016 and December 2017. Demographic data, comorbidities, and laryngeal diagnoses were extracted from the electronic medical record. The charts of patients with myositis were reviewed further to ascertain details of their laryngeal symptoms and myositis disease course. Associations between myositis and dysphonia/dysphagia were evaluated using binary regression and multinomial logistic regression models to adjust for age, sex, race, and smoking status.

resultsOf 4252 patients, sixteen had myositis. Compared to 4236 controls, these patients had significantly higher odds of presenting with muscular voice disorders (adjusted odds ratio (OR*) = 4.503, p* = 0.005) and dysphagia (OR* = 6.823, p* < 0.001). A majority (64.3%, CI:35.6-93.0%) of myositis patients had laryngeal pathology among the presenting symptoms of their myositis. Across all diagnostic categories, there was a non-significant trend towards better outcomes in patients receiving specific interventions for their laryngeal symptoms.

conclusionsMuscular voice disorders and dysphagia are significantly overrepresented in myositis patients presenting to a laryngology clinic, and in these patients, both are frequently among the presenting symptoms of myositis.

Indexed as

Age FactorsAutoimmune DiseasesDeglutition DisordersDysphoniaEarly DiagnosisFemaleHumansMaleMiddle AgedMyositisQuality of LifeRetrospective StudiesSex FactorsSmokingDeglutition disordersDermatomyositisDysphoniaMyositisPolymyositisVelopharyngeal insufficiency

Identifiers

PMID33038783
PMCPMC7722093
OpenAlexW3090805226

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.