Evidence map›Paper›PMID 33038669›Full record

ArticleNeuroImage. Clinical2020

Quantitative MRI demonstrates abnormalities of the third ventricle subventricular zone in neurofibromatosis type-1 and sporadic paediatric optic pathway glioma.

Natalie R Boonzaier, Patrick W Hales, Felice D'Arco, Bronwen C Walters, Ramneek Kaur, Kshitij Mankad, Jessica Cooper, Alki Liasis, Victoria Smith, Patricia O'Hare and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Natalie R BoonzaierDevelopmental Imaging and Biophysics Section, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, UK.
Patrick W HalesDevelopmental Imaging and Biophysics Section, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, UK. Electronic address: p.hales@ucl.ac.uk.
Felice D'ArcoGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Bronwen C WaltersGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Ramneek KaurDevelopmental Imaging and Biophysics Section, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, UK.
Kshitij MankadGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Jessica CooperGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Alki LiasisGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK; University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, Pittsburgh, USA.
Victoria SmithGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Patricia O'HareGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Darren HargraveDevelopmental Imaging and Biophysics Section, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, UK; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Christopher A ClarkDevelopmental Imaging and Biophysics Section, Developmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, UK.
Great Ormond Street Hospital for Children NHS Foundation Trust · GBUniversity College London · GBChildren's Hospital of Pittsburgh · US

Funding

Department of Health
6 · The paper itself

Abstract

backgroundThe subventricular zone of the third ventricle (TVZ) is a germinal stem cell niche, identified as the possible location of optic pathway glioma (OPG) cell origin. Paediatric OPGs are predominantly diagnosed as low-grade astrocytomas, which are either sporadic or are associated with neurofibromatosis type-1 (NF1). These tumours often cause a significant impairment to visual acuity (VA). Infiltrative/invasive tumour activity is associated with increased apparent diffusion coefficient (ADC) and cerebral blood flow (CBF). This study aimed to determine whether TVZ imaging features differed between sporadic-OPG, NF1-OPG and controls, and whether the ADC and CBF profile at the germinal stem cell niche (the TVZ) correlated with the primary outcome of VA.

methodsADC and CBF MRI data were acquired from 30 paediatric OPG patients (median age 6 years; range 8 months-17 years), along with VA measurements, during clinical surveillance of their tumour. Values for mean ADC and maximum CBF were measured at the TVZ, and normalized to normal-appearing grey matter. These values were compared between the two OPG groups and the healthy control subjects, and multivariate linear regression was used to test the linear association between these values and patient's VA.

resultsIn the TVZ, normalized mean ADC was higher in NF1-associated OPG patients (N = 15), compared to both sporadic OPG patients (N = 15; p = 0.010) and healthy controls (N = 14; p < 0.001). In the same region, normalized maximum CBF was higher in sporadic OPG patients compared to both NF1-OPG patients (p = 0.016) and healthy controls (p < 0.001). In sporadic OPG patients only, normalized mean ADC in the TVZ was significantly correlated with visual acuity (R

conclusionQuantitative MRI detects TVZ abnormalities in both sporadic and NF1-OPG patients, and identifies TVZ features that differentiate the two. TVZ features may be useful MRI markers of interest in future predictive studies involving sporadic OPG.

Indexed as

Neurofibromatosis 1Optic Nerve GliomaThird VentricleChildHumansInfantLateral VentriclesMagnetic Resonance ImagingNeurofibromatosis type-1Optic pathway gliomaPaediatricQuantitative magnetic resonance imagingThird ventricle subventricular zone

Identifiers

PMID33038669
PMCPMC7554210
OpenAlexW3091537544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.